IpiRecord: IPI00406306

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
replication fork	C		IDA	ISS
cytoplasm	C		IDA IDA IDA ISS	ISS ISS IMP ISS
endoplasmic reticulum	C		IEA	IEA
mitochondrion	C			ISS ISS
nucleolus	C			ISS ISS
nucleoplasm	C			ISS
nuclear matrix	C			ISS
cytosol	C		IDA	ISS
nucleus	C	IEA	IDA IDA IDA ISS IDA	ISS ISS IMP IEA ISS
insoluble fraction	C			ISS
enzyme binding	F			ISS
protein N-terminus binding	F			ISS
ATP binding	F			ISS ISS
transcription factor activity	F	IEA	IDA IDA IDA	ISS ISS IEA
RNA polymerase II transcription factor activity	F			TAS
chromatin binding	F		ISS
nuclease activity	F			ISS
protein binding	F	IPI	IPI IPI IPI IPI IPI IPI IPI IPI IPI IPI	ISS ISS IPI
copper ion binding	F			ISS ISS
zinc ion binding	F	IEA	IEA	ISS IEA
DNA binding	F		IDA IDA IDA IDA	ISS
metal ion binding	F	IEA	IEA	IEA
protein heterodimerization activity	F			ISS
DNA strand annealing activity	F			ISS ISS
cell cycle	P	IEA	IEA	IEA
central nervous system development	P		IGI
response to DNA damage stimulus	P		IDA IMP ISS IDA	ISS ISS
cellular response to glucose starvation	P		ISS
cell aging	P			ISS ISS
cell proliferation	P			ISS
positive regulation of transcription	P		IDA IGI	ISS
induction of apoptosis	P		IDA IMP	ISS
negative regulation of apoptosis	P		IMP	ISS
multicellular organismal development	P			ISS
regulation of mitochondrial membrane permeability	P			ISS
regulation of progression through cell cycle	P		IMP	ISS
base-excision repair	P			ISS
cell differentiation	P			ISS
response to gamma radiation	P		IDA
embryonic development ending in birth or egg hatching	P		IGI	ISS
negative regulation of neuroblast proliferation	P		IGI
negative regulation of cell growth	P			TAS ISS ISS
response to UV	P		IMP IDA	ISS
in utero embryonic development	P		IGI IGI
negative regulation of cell proliferation	P		IGI IGI IGI IGI
positive regulation of transcription from RNA polymerase II promoter	P		IDA IDA ISS	ISS
cell cycle arrest	P			ISS
G1 DNA damage checkpoint	P		IMP	ISS
regulation of cell proliferation	P		IMP	ISS
caspase activation via cytochrome c	P			ISS ISS
transcription	P		IEA	IEA
apoptosis	P	IEA	IGI IDA	ISS ISS IEA ISS
nucleotide-excision repair	P			ISS ISS
positive regulation of neuron apoptosis	P		IMP IDA IMP IGI
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis	P		IMP ISS ISS IGI	ISS ISS
regulation of transcription, DNA-dependent	P	IEA	IDA	ISS ISS
regulation of apoptosis	P		ISS
protein tetramerization	P			ISS
response to X-ray	P		IDA	ISS
protein import into nucleus, translocation	P		IDA	ISS
negative regulation of progression through cell cycle	P	IEA	IEA	IEA
positive regulation of transcription, DNA-dependent	P		IDA
positive regulation of apoptosis	P			IMP
ER overload response	P		ISS
regulation of neuron apoptosis	P		IGI
protein complex assembly	P			ISS
regulation of cellular pH	P			IMP
release of cytochrome c from mitochondria	P		IDA
negative regulation of fibroblast proliferation	P		IMP	ISS
negative regulation of DNA replication	P		IDA IMP	ISS
negative regulation of helicase activity	P			ISS
DNA damage response, signal transduction by p53 class mediator	P		IGI IGI IDA IDA	ISS
regulation of transcription from RNA polymerase II promoter	P			TAS

Cellular Component

Biological Process

Molecular Function

Phenotype (27)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
craniofacial phenotype	MP		Un
skin/coat/nails phenotype	MP		Un Un Un Un Un Un Un
cellular phenotype	MP		Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un
homeostasis/metabolism phenotype	MP		Un
behavior/neurological phenotype	MP		Un
endocrine/exocrine gland phenotype	MP		Un Un Un
immune system phenotype	MP		Un Un Un
embryogenesis phenotype	MP		Un Un Un Un Un
lethality-embryonic/perinatal	MP		Un Un Un Un Un Un Un Un Un Un Un Un Un
muscle phenotype	MP		Un
skeleton phenotype	MP		Un Un Un Un
lethality-postnatal	MP		Un
renal/urinary system phenotype	MP		Un
growth/size phenotype	MP		Un Un Un Un Un
respiratory system phenotype	MP		Un Un
vision/eye phenotype	MP		Un Un
tumorigenesis	MP		Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un Un
digestive/alimentary phenotype	MP		Un
normal phenotype	MP		Un Un Un
cardiovascular system phenotype	MP		Un Un Un Un
life span-post-weaning/aging	MP		Un Un Un Un Un Un Un Un Un Un Un Un
hematopoietic system phenotype	MP		Un Un
reproductive system phenotype	MP		Un Un Un
no phenotypic analysis	MP		Un
nervous system phenotype	MP		Un Un Un
abnormal apoptosis	N			ISS
increased tumor incidence	N			ISS

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
Coronary Restenosis	D			ISS

Pathway (6)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
Wnt signaling pathway	W			IEA
programmed cell death pathway	W			IEA
amyotrophic lateral sclerosis disease pathway	W			IEA
p53-dependent G1/S DNA damage checkpoint pathway	W			IEA
mitogen activated protein kinase signaling pathway	W			IEA
Huntington disease pathway	W			IEA

KEGG Pathway (10)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Glioma (05214)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Chronic myeloid leukemia (05220)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Cell cycle (04110)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Apoptosis (04210)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
MAPK signaling pathway (04010)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Amyotrophic lateral sclerosis (ALS) (05030)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Wnt signaling pathway (04310)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Colorectal cancer (05210)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Huntington's disease (05040)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Pancreatic cancer (05212)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway