IpiRecord: IPI00002520

IPI00002520 - SHMT2, SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL PRECURSOR.
Uniprot Accession: Q8N1A5
Uniprot ID: Q8N1A5_HUMAN
Mapping: Chr 12, 55909819 - 55914981
Entrez Gene: 6472
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7107)
Rat: Shmt2, SERINE HYDROXYMETHYLTRANSFERASE.
Mouse: Shmt2, SERINE HYDROXYMETHYLTRANSFERASE.
Human: SHMT2, SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL PRECURSOR.
Human: SHMT2, HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL.
Human: SHMT2, SERINE HYDROXYMETHYLTRANSFERASE (FRAGMENT).
Human: SHMT2, SERINE HYDROXYMETHYLTRANSFERASE (FRAGMENT).
Human: SHMT2, 26 KDA PROTEIN.
Human: SHMT2, 45 KDA PROTEIN.
Human: SHMT2, 10 KDA PROTEIN.
Human: SHMT2, 11 KDA PROTEIN.
Human: SHMT2, 13 KDA PROTEIN.
Human: SHMT2, 16 KDA PROTEIN.
Human: SHMT2, 7 KDA PROTEIN.
Human: SHMT2, 18 KDA PROTEIN.
Human: SHMT2, 20 KDA PROTEIN.

Annotations for SHMT2 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
mitochondrionCTAS IDA RCA IDA TAS ISS ISS 
mitochondrial inner membraneCIDA ISS 
protein bindingFIPI IPI 
glycine hydroxymethyltransferase activityFIEA RCA IDA TAS ISS IEA 
transferase activityFIEA IEA IEA 
catalytic activityFIEA 
pyridoxal phosphate bindingFIEA TAS IEA 
methyltransferase activityFRCA ISS 
one-carbon compound metabolic processPIEA IEA 
glycine metabolic processPIEA TAS IEA 
L-serine metabolic processPIEA TAS IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (0)

There are no Mammalian Phenotype Ontology annotations for this protein in the database

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (3)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
folate mediated one-carbon metabolic pathwayWTAS
pathway of folate cycle/metabolismWTAS
glycine, serine and threonine metabolic pathwayWTAS

KEGG Pathway (5)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
One carbon pool by folate (00670)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Glycine, serine and threonine metabolism (00260)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Lysine degradation (00310)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Methane metabolism (00680)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Cyanoamino acid metabolism (00460)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway