IpiRecord: IPI00004566

IPI00004566 - ITK, TYROSINE-PROTEIN KINASE ITK/TSK.
Uniprot Accession: Q7Z318
Uniprot ID: Q7Z318_HUMAN
Mapping: Chr 5, 156540432 - 156614687
Entrez Gene: 3702
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_9301)
Rat: Itk_predicted, SIMILAR TO IL2-INDUCIBLE T-CELL KINASE ISOFORM 2.
Mouse: Itk, TYROSINE-PROTEIN KINASE ITK/TSK.
Mouse: Itk, IL2-INDUCIBLE T-CELL KINASE.
Mouse: Itk, IL2-INDUCIBLE T-CELL KINASE.
Rat: Itk_predicted, SIMILAR TO IL2-INDUCIBLE T-CELL KINASE ISOFORM 1.
Rat: Itk_predicted, 31 KDA PROTEIN.
Human: ITK, TYROSINE-PROTEIN KINASE ITK/TSK.
Human: ITK, IL2-INDUCIBLE T-CELL KINASE VARIANT (FRAGMENT).

Annotations for ITK and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
membraneCIEA IEA 
protein-tyrosine kinase activityFIEA IEA IEA 
non-membrane spanning protein tyrosine kinase activityFTAS ISS 
protein serine/threonine kinase activityFISS 
nucleotide bindingFIEA IEA 
ATP bindingFIEA IEA IEA IEA 
zinc ion bindingFIEA IEA 
kinase activityFIEA IEA 
metal ion bindingFIEA IEA 
protein kinase activityFIEA 
transferase activityFIEA IEA 
protein amino acid phosphorylationPIEA IEA IEA 
cellular defense responsePTAS ISS 
intracellular signaling cascadePIEA IEA IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (2)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
immune system phenotypeMPUn Un
hematopoietic system phenotypeMPUn Un

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
T cell receptor signaling pathway (04660)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Leukocyte transendothelial migration (04670)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway