IpiRecord: IPI00005630

IPI00005630 - E2F1, TRANSCRIPTION FACTOR E2F1.
Uniprot Accession: Q01094
Uniprot ID: E2F1_HUMAN
Mapping: Chr 20, 31727147 - 31737871
Entrez Gene: 1869
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_3918)
Rat: E2f1, SIMILAR TO TRANSCRIPTION FACTOR E2F1.
Mouse: E2f1, TRANSCRIPTION FACTOR E2F1.
Mouse: E2f1, SEQUENCE.
Rat: E2f1, SIMILAR TO TRANSCRIPTION FACTOR E2F1.
Human: E2F1, TRANSCRIPTION FACTOR E2F1.
Human: E2F1, UNCHARACTERIZED PROTEIN E2F1.
Human: E2F1, SIMILAR TO E2F TRANSCRIPTION FACTOR 1 (FRAGMENT).

Annotations for E2F1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmCIEA IDA ISS IEA 
transcription factor complexCIEA IDA ISS IEA 
nucleusCIEA IDA IDA ISS IEA 
transcription corepressor activityFTAS ISS 
transcription activator activityFIEA IDA IDA ISS IEA 
transcription factor activityFTAS IDA IEA IDA IDA IDA IDA TAS ISS ISS IEA 
protein bindingFIPI IPI IPI IPI ISS ISS IPI 
DNA bindingFISS 
transcription factor bindingFIPI 
regulation of progression through cell cyclePIEA IDA ISS IEA 
G1/S transition of mitotic cell cyclePTAS 
forebrain developmentPIEA IMP ISS IEA 
G1 phase of mitotic cell cyclePTAS ISS 
regulation of transcriptionPIDA IDA ISS 
cell proliferationPTAS ISS 
apoptosisPTAS IDA IDA ISS ISS IEA 
positive regulation of transcription from RNA polymerase II promoterPIEA IDA ISS IEA 
cell cyclePIEA IEA 
transcriptionPIEA IEA IEA 
regulation of transcription, DNA-dependentPIEA IDA ISS IEA 
positive regulation of transcription, DNA-dependentPIDA IDA IDA ISS 
negative regulation of transcription from RNA polymerase II promoterPTAS ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (21)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn
life span-post-weaning/agingMPUn
endocrine/exocrine gland phenotypeMPUn
growth/size phenotypeMPUn
immune system phenotypeMPUn
hearing/vestibular/ear phenotypeMPUn
reproductive system phenotypeMPUn
hematopoietic system phenotypeMPUn
digestive/alimentary phenotypeMPUn
tumorigenesisMPUn
abnormal thymus developmentNISS
exocrine pancreas hypoplasiaNISS
abnormal apoptosisNISSISS
decreased circulating insulin levelNISS
cellular dysplasiaNISS
increased T cell proliferationNISS
abnormal pancreas secretionNISS
abnormal islet of Langerhans morphologyNISS
increased insulin sensitivityNISS
increased tumor incidenceNISS
small testisNISS

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (4)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Glioma (05214)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Chronic myeloid leukemia (05220)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cell cycle (04110)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pancreatic cancer (05212)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway