IpiRecord: IPI00005732

IPI00005732 - ACVR1B, ISOFORM 1 OF ACTIVIN RECEPTOR TYPE-1B PRECURSOR.
Uniprot Accession: P36896-1
Uniprot ID: ACV1B_HUMAN
Mapping: Chr 12, 50494095 - 50677124
Entrez Gene: 91
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7451)
Rat: Acvr1b, ACTIVIN RECEPTOR TYPE-1B PRECURSOR.
Mouse: Acvr1b, ACTIVIN RECEPTOR TYPE-1B PRECURSOR.
Human: ACVR1B, ISOFORM 1 OF ACTIVIN RECEPTOR TYPE-1B PRECURSOR.
Human: ACVR1B, ISOFORM 2 OF ACTIVIN RECEPTOR TYPE-1B PRECURSOR.
Human: ACVR1B, ISOFORM 3 OF ACTIVIN RECEPTOR TYPE-1B PRECURSOR.
Human: ACVR1B, 8 KDA PROTEIN.

Annotations for ACVR1B and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cell surfaceCIEA 
membraneCRCA ISS IEA 
activin receptor complexCISS IMP 
integral to plasma membraneCTAS ISS ISS IEA 
extracellular spaceCISS 
integral to membraneCRCA ISS 
kinase activityFIEA 
activin bindingFIPI ISS IEA 
SMAD bindingFIMP IEA 
metal ion bindingFIEA 
growth factor bindingFIEA 
protein kinase activityFRCA ISS 
protein-tyrosine kinase activityFISS 
protein serine/threonine kinase activityFIEA IEA IEA IEA 
manganese ion bindingFIEA IEA 
activin receptor activity, type IFTAS IMP 
transmembrane receptor protein serine/threonine kinase activityFTAS TAS ISS 
receptor signaling protein serine/threonine kinase activityFIMP 
receptor activityFIEA IEA 
transferase activityFIEA IEA 
transforming growth factor beta receptor activityFRCA ISS IEA 
magnesium ion bindingFIEA IEA 
transforming growth factor beta receptor activity, type IFISS 
ATP bindingFIEA IEA IEA IEA 
nucleotide bindingFIEA IEA 
protein amino acid phosphorylationPIEA RCA TAS ISS IMP IEA 
in utero embryonic developmentPIMP IMP ISS IEA 
negative regulation of cell growthPIEA 
G1/S transition of mitotic cell cyclePIEA 
induction of apoptosisPIEA 
positive regulation of erythrocyte differentiationPIEA 
hair follicle developmentPIMP IEA 
embryonic developmentPIMP ISS IEA 
cell surface receptor linked signal transductionPTAS ISS 
regulation of transcriptionPIEA 
signal transductionPIEA 
transmembrane receptor protein serine/threonine kinase signaling pathwayPISS 
mesoderm developmentPISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (6)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn
embryogenesis phenotypeMPUn
lethality-embryonic/perinatalMPUn
nervous system phenotypeMPUn
respiratory system phenotypeMPUn
life span-post-weaning/agingMPUn

Disease (2)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Pancreatic NeoplasmsDISS
Myocardial IschemiaDIEP

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
activin signaling pathwayWTAS

KEGG Pathway (7)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Chronic myeloid leukemia (05220)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
TGF-beta signaling pathway (04350)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Adherens junction (04520)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
MAPK signaling pathway (04010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Colorectal cancer (05210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cytokine-cytokine receptor interaction (04060)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pancreatic cancer (05212)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway