IpiRecord: IPI00007793

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
extracellular region	C	NAS NAS	IEA	IEA
extracellular space	C	TAS	IDA IDA IDA IDA IDA IDA	ISS IEA
interleukin-6 receptor binding	F	NAS	IEA	IDA IDA IEA
growth factor activity	F		IEA
protein binding	F	IEA	IPI	ISS IEA
cytokine activity	F	IEA	IDA IDA	ISS IDA IEA
immune response	P		IEA	IEA
cell surface receptor linked signal transduction	P	TAS
negative regulation of apoptosis	P	IDA		IEA
positive regulation of protein biosynthetic process	P	IDA
defense response to protozoan	P	IEA	IMP
regulation of circadian sleep/wake cycle, non-REM sleep	P			IMP
negative regulation of hormone secretion	P	IEA	IDA
neutrophil apoptosis	P	IDA	IDA IMP	ISS IEA
negative regulation of cell proliferation	P	TAS
positive regulation of JAK-STAT cascade	P			IDA
cell-cell signaling	P	NAS
humoral immune response	P	TAS
negative regulation of chemokine biosynthetic process	P	ISS	IDA IMP	ISS IEA
acute-phase response	P	IEA	IEA	IEA
positive regulation of cell proliferation	P	TAS
positive regulation of T-helper 2 cell differentiation	P	IEA	IDA	IEA
response to mechanical stimulus	P			IEP
positive regulation of transcription, DNA-dependent	P		IDA

Cellular Component

Biological Process

Molecular Function

Phenotype (12)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
behavior/neurological phenotype	MP		Un
homeostasis/metabolism phenotype	MP		Un Un
immune system phenotype	MP		Un Un Un
skeleton phenotype	MP		Un Un
nervous system phenotype	MP		Un Un Un
touch/vibrissae phenotype	MP		Un
tumorigenesis	MP		Un
digestive/alimentary phenotype	MP		Un
hematopoietic system phenotype	MP		Un Un
growth/size phenotype	MP		Un
life span-post-weaning/aging	MP		Un
liver/biliary system phenotype	MP		Un

Disease (6)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
Obesity	D			ISS
Intracranial Aneurysm	D			ISS
Periodontal Diseases	D			ISS
Cerebrovascular Accident	D			ISS
Periodontitis	D			ISS
Hypertension	D			ISS

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
Interleukin-6 signaling pathway	W			ISS

KEGG Pathway (5)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Prion disease (05060)	Present in KEGG pathway	Not present in KEGG pathway	Not present in KEGG pathway
Toll-like receptor signaling pathway (04620)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Jak-STAT signaling pathway (04630)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Hematopoietic cell lineage (04640)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Cytokine-cytokine receptor interaction (04060)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway