IpiRecord: IPI00008215

IPI00008215 - ME1, NADP-DEPENDENT MALIC ENZYME.
Uniprot Accession: Q8WVX2
Uniprot ID: Q8WVX2_HUMAN
Mapping: Chr 6, 83976827 - 84197509
Entrez Gene: 4199
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_8218)
Rat: Me1, MALIC ENZYME 1.
Mouse: Me1, NADP-DEPENDENT MALIC ENZYME.
Mouse: Me1, MOD-1 NULL MALIC ENZYME (FRAGMENT).
Human: ME1, NADP-DEPENDENT MALIC ENZYME.

Annotations for ME1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmCIEA IEA 
cytosolCISS IDA 
soluble fractionCIDA ISS IDA 
electron carrier activityFTAS ISS 
NAD bindingFTAS IEA ISS IEA 
manganese ion bindingFIDA ISS ISS 
malic enzyme activityFIEA IDA 
metal ion bindingFIEA IEA IEA 
NADP bindingFTAS ISS IDA 
ADP bindingFTAS ISS 
oxidoreductase activityFIEA IEA 
malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activityFIDA ISS ISS ISS ISS ISS IDA 
malate dehydrogenase (decarboxylating) activityFIEA 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorFIEA 
malate metabolic processPIDA IDA ISS ISS ISS 
response to carbohydrate stimulusPTAS ISS 
carbohydrate metabolic processPNAS ISS 
NADP biosynthetic processPTAS ISS 
response to hormone stimulusPISS IDA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (3)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
homeostasis/metabolism phenotypeMPUn
life span-post-weaning/agingMPUn
no phenotypic analysisMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (2)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
pyruvate metabolic pathwayWIEA
carbon fixation pathwayWIEA

KEGG Pathway (3)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
PPAR signaling pathway (03320)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Carbon fixation (00710)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pyruvate metabolism (00620)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway