IpiRecord: IPI00009308

IPI00009308 - CCL2, SMALL-INDUCIBLE CYTOKINE A2 PRECURSOR.
Uniprot Accession: P13500
Uniprot ID: CCL2_HUMAN
Mapping: Chr 17, 29606409 - 29608329
Entrez Gene: 6347
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_9765)
Rat: Ccl2, SMALL-INDUCIBLE CYTOKINE A2 PRECURSOR.
Mouse: Ccl2, SMALL-INDUCIBLE CYTOKINE A2 PRECURSOR.
Human: CCL2, SMALL-INDUCIBLE CYTOKINE A2 PRECURSOR.
Human: CCL2, MCP1.

Annotations for CCL2 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
membraneCIEA 
cell somaCIDA 
extracellular regionCIEA IEA IEA 
cytoplasmCIDA 
extracellular spaceCTAS RCA ISS ISS IEA 
chemokine activityFTAS IEA IEA NAS TAS ISS IEA 
signal transducer activityFTAS TAS 
protein kinase activityFTAS ISS 
CCR2 chemokine receptor bindingFIMP 
protein bindingFIPI ISS IEA 
cytokine activityFIEA IEA 
G-protein-coupled receptor bindingFIEA IDA IDA ISS IEA 
transforming growth factor beta receptor signaling pathwayPIMP 
cytokine and chemokine mediated signaling pathwayPIMP 
immune responsePIEA IEA IEA 
viral genome replicationPTAS ISS 
inflammatory responsePIEA IEA IEP IEA 
positive regulation of endothelial cell proliferationPIMP 
cellular calcium ion homeostasisPTAS ISS IDA 
humoral immune responsePTAS ISS 
JAK-STAT cascadePTAS ISS 
cell-cell signalingPNR ISS 
G-protein signaling, coupled to cyclic nucleotide second messengerPTAS ISS 
protein amino acid phosphorylationPTAS ISS 
response to bacteriumPISS 
anti-apoptosisPIDA ISS IEA 
cell adhesionPTAS ISS 
chemotaxisPTAS IEA ISS IEA 
organ morphogenesisPTAS ISS 
signal transductionPIEA 
vascular endothelial growth factor receptor signaling pathwayPIMP 
chemokinesisPTAS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (3)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
immune system phenotypeMPUn
cardiovascular system phenotypeMPUn
hematopoietic system phenotypeMPUn

Disease (8)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Temporal ArteritisDISS
Cardiovascular DiseasesDISS
IschemiaDISS
Myocardial InfarctionDISS
Endomyocardial FibrosisDIEP
Cerebrovascular AccidentDISS
LipodystrophyDISS
Heart Failure, CongestiveDIEP

Pathway (2)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
Angiotensin II signaling pathwayWIEP
vascular endothelial growth factor signaling pathwayWIMP

KEGG Pathway (1)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Cytokine-cytokine receptor interaction (04060)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway