IPI report for IPI00014256

IpiRecord: IPI00014256

IPI00014256 - ARHGEF6, ISOFORM 1 OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.
Uniprot Accession: Q7Z3W1
Uniprot ID: Q7Z3W1_HUMAN
Mapping: Chr X, 135575372 - 135691913
Entrez Gene: 9459
Entrez MapView:
+All IPI Database Cross References UniProtKB/Swiss-Prot: Q15052-1 UniProtKB/Swiss-Prot: ARHG6_HUMAN Vega: OTTHUMP00000024134 REFSEQ_REVIEWED: NP_004831 REFSEQ_REVIEWED: GI:22027525 UniProtKB/TrEMBL: Q7Z3W1 UniProtKB/TrEMBL: Q7Z3W1_HUMAN ENSEMBL: ENSP00000359657 ENSEMBL: ENSG00000129675 H-InvDB: HIT000052272 UniParc: UPI0000001C8E HGNC: 685 Entrez Gene: 9459 UniGene: Hs.522795 CCDS: CCDS14660.1 UTRdb: BB107123 UTRdb: BB342532 UTRdb: CC319333 RZPD: Hs.522795 InterPro: IPR001715 InterPro: IPR001849 InterPro: IPR000219 InterPro: IPR001452 InterPro: IPR003096 Pfam: PF00307 Pfam: PF00169 Pfam: PF00621 Pfam: PF00018 PRINTS: PR00452 PRINTS: PR00888 ProDom: PD000066 SMART: SM00033 SMART: SM00233 SMART: SM00325 SMART: SM00326 PROSITE: PS50021 PROSITE: PS50010 PROSITE: PS50003 PROSITE: PS50002 SUPERFAMILY: SSF50044 GENE3D: G3DSA:1.20.900.10

IPI00014256 - ARHGEF6, ISOFORM 1 OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.

Uniprot Accession: Q7Z3W1

Uniprot ID: Q7Z3W1_HUMAN

Mapping: Chr X, 135575372 - 135691913

Entrez Gene: 9459

Entrez MapView: Geneprod

+All IPI Database Cross References

IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_15062)
Rat: arhgef6, RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.
Mouse: Arhgef6, RAC/CDC42 GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 6.
Mouse: Arhgef6, RAC/CDC42 GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 6.
Human: ARHGEF6, ISOFORM 1 OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.
Human: ARHGEF6, ISOFORM 2 OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.
Human: ARHGEF6, UNCHARACTERIZED PROTEIN ARHGEF6.

IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_15062)

Rat: arhgef6, RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.

Mouse: Arhgef6, RAC/CDC42 GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 6.

Human: ARHGEF6, ISOFORM 1 OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.

Human: ARHGEF6, ISOFORM 2 OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.

Human: ARHGEF6, UNCHARACTERIZED PROTEIN ARHGEF6.

Annotations for ARHGEF6 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
cellular_component	C		ND	ND
intracellular	C	IEA	IEA	ISS IEA
guanyl-nucleotide exchange factor activity	F		IEA IEA	IEA
GTPase activator activity	F			ISS
molecular_function	F		ND	ND
Rho guanyl-nucleotide exchange factor activity	F	IEA	IEA	ISS IEA
apoptosis	P			ISS
intracellular signaling cascade	P		IEA
regulation of Rho protein signal transduction	P	IEA	IEA	IEA
JNK cascade	P			ISS
biological_process	P		ND	ND

Cellular Component

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Phenotype (0)

There are no Mammalian Phenotype Ontology annotations for this protein in the database

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
Mental Retardation	D			ISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Regulation of actin cytoskeleton (04810)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Pancreatic cancer (05212)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway