IpiRecord: IPI00016703

IPI00016703 - DHCR24, 24-DEHYDROCHOLESTEROL REDUCTASE PRECURSOR.
Uniprot Accession: Q3LIE7
Uniprot ID: Q3LIE7_HUMAN
Mapping: Chr 1, 55087888 - 55125493
Entrez Gene: 1718
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_5547)
Rat: Dhcr24, 32 KDA PROTEIN.
Mouse: Dhcr24, 24-DEHYDROCHOLESTEROL REDUCTASE PRECURSOR.
Rat: Dhcr24, 3-BETA-HYDROXYSTEROL DELTA 24 REDUCTASE.
Human: DHCR24, 24-DEHYDROCHOLESTEROL REDUCTASE PRECURSOR.
Human: DHCR24, PROTEIN.

Annotations for DHCR24 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
Golgi apparatusCIEA RCA ISS 
endoplasmic reticulumCIDA RCA ISS ISS ISS 
nucleusCIDA ISS ISS 
integral to membraneCIEA RCA ISS 
extracellular spaceCRCA ISS 
endoplasmic reticulum membraneCNAS ISS 
cellular_componentCND 
cytoplasmCISS 
membraneCIEA 
FAD bindingFIEA 
oxidoreductase activityFIEA RCA ISS NAS 
electron carrier activityFRCA ISS 
MAP kinase tyrosine/serine/threonine phosphatase activityFISS 
peptide antigen bindingFIPI ISS ISS 
enzyme bindingFIPI ISS ISS 
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptorFIDA ISS 
plasminogen activationPIEA IMP 
cholesterol metabolic processPIMP 
negative regulation of cell proliferationPIMP 
protein localizationPIEA IMP 
negative regulation of caspase activityPIDA ISS ISS 
inactivation of MAPK activityPISS 
sterol metabolic processPIMP 
Ras protein signal transductionPIMP 
cell cycle arrestPNAS ISS 
response to oxidative stressPIEP ISS ISS 
apoptosisPNAS ISS 
skin developmentPISS ISS 
membrane organization and biogenesisPIEA IMP 
amyloid precursor protein catabolic processPIEA IMP 
cholesterol biosynthetic processPISS NAS ISS IMP IMP ISS ISS 
electron transportPIEA 
anti-apoptosisPIDA ISS ISS 
neuroprotectionPNAS ISS 
tissue developmentPIMP IMP ISS ISS 
male genitalia developmentPIEA IMP 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (6)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
adipose tissue phenotypeMPUn
endocrine/exocrine gland phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
lethality-embryonic/perinatalMPUn
reproductive system phenotypeMPUn
growth/size phenotypeMPUn

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Lipid Metabolism, Inborn ErrorsDISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (1)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Biosynthesis of steroids (00100)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway