| IPI00016703 - DHCR24, 24-DEHYDROCHOLESTEROL REDUCTASE PRECURSOR. | |
|---|---|
| Uniprot Accession: Q3LIE7 | |
| Uniprot ID: Q3LIE7_HUMAN | |
| Mapping: Chr 1, 55087888 - 55125493 | |
| Entrez Gene: 1718 | |
| Entrez MapView: |
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| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_5547) |
|---|
| Rat: Dhcr24, 32 KDA PROTEIN. |
| Mouse: Dhcr24, 24-DEHYDROCHOLESTEROL REDUCTASE PRECURSOR. |
| Rat: Dhcr24, 3-BETA-HYDROXYSTEROL DELTA 24 REDUCTASE. |
| Human: DHCR24, 24-DEHYDROCHOLESTEROL REDUCTASE PRECURSOR. |
| Human: DHCR24, PROTEIN. |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Golgi apparatus | C | IEA | RCA | ISS |
| endoplasmic reticulum | C | IDA | RCA | ISS ISS ISS |
| nucleus | C | IDA | ISS ISS | |
| integral to membrane | C | IEA | RCA | ISS |
| extracellular space | C | RCA | ISS | |
| endoplasmic reticulum membrane | C | NAS | ISS | |
| cellular_component | C | ND | ||
| cytoplasm | C | ISS | ||
| membrane | C | IEA | ||
| FAD binding | F | IEA | ||
| oxidoreductase activity | F | IEA | RCA | ISS NAS |
| electron carrier activity | F | RCA | ISS | |
| MAP kinase tyrosine/serine/threonine phosphatase activity | F | ISS | ||
| peptide antigen binding | F | IPI | ISS ISS | |
| enzyme binding | F | IPI | ISS ISS | |
| oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor | F | IDA | ISS | |
| plasminogen activation | P | IEA | IMP | |
| cholesterol metabolic process | P | IMP | ||
| negative regulation of cell proliferation | P | IMP | ||
| protein localization | P | IEA | IMP | |
| negative regulation of caspase activity | P | IDA | ISS ISS | |
| inactivation of MAPK activity | P | ISS | ||
| sterol metabolic process | P | IMP | ||
| Ras protein signal transduction | P | IMP | ||
| cell cycle arrest | P | NAS | ISS | |
| response to oxidative stress | P | IEP | ISS ISS | |
| apoptosis | P | NAS | ISS | |
| skin development | P | ISS | ISS | |
| membrane organization and biogenesis | P | IEA | IMP | |
| amyloid precursor protein catabolic process | P | IEA | IMP | |
| cholesterol biosynthetic process | P | ISS NAS | ISS IMP IMP | ISS ISS |
| electron transport | P | IEA | ||
| anti-apoptosis | P | IDA | ISS ISS | |
| neuroprotection | P | NAS | ISS | |
| tissue development | P | IMP | IMP | ISS ISS |
| male genitalia development | P | IEA | IMP |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| adipose tissue phenotype | MP | Un | ||
| endocrine/exocrine gland phenotype | MP | Un | ||
| homeostasis/metabolism phenotype | MP | Un | ||
| lethality-embryonic/perinatal | MP | Un | ||
| reproductive system phenotype | MP | Un | ||
| growth/size phenotype | MP | Un |
| DO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Lipid Metabolism, Inborn Errors | D | ISS |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| Biosynthesis of steroids (00100) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |