IpiRecord: IPI00016802

IPI00016802 - SIRT1, NAD-DEPENDENT DEACETYLASE SIRTUIN-1.
Uniprot Accession: Q96EB6
Uniprot ID: SIRT1_HUMAN
Mapping: Chr 10, 69314433 - 69348153
Entrez Gene: 23411
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_14474)
Rat: Sirt1_predicted, SIMILAR TO NAD-DEPENDENT DEACETYLASE SIRTUIN-1.
Mouse: Sirt1, NAD-DEPENDENT DEACETYLASE SIRTUIN-1.
Rat: Sirt1_predicted, SIMILAR TO NAD-DEPENDENT DEACETYLASE SIRTUIN-1.
Rat: Sirt1_predicted, PROTEIN.
Human: SIRT1, NAD-DEPENDENT DEACETYLASE SIRTUIN-1.

Annotations for SIRT1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
nucleusCIEA IDA IDA ISS 
chromatin silencing complexCIEA RCA ISS IEA 
cellular_componentCND 
hydrolase activityFIEA IEA 
DNA bindingFIEA RCA ISS IEA 
NAD-dependent histone deacetylase activityFIEA IDA ISS 
molecular_functionFND 
metal ion bindingFIEA IEA 
NAD+ ADP-ribosyltransferase activityFTAS 
transcription repressor activityFIEA IDA ISS 
zinc ion bindingFIEA IEA 
response to nutrient levelsPIEP 
chromatin silencingPTAS RCA ISS IEA 
histone deacetylationPIEA IDA ISS 
cell differentiationPIEA IEA 
apoptosisPIEA IEA 
striated muscle developmentPIEA IEA 
protein amino acid ADP-ribosylationPTAS 
spermatogenesisPIEA IMP ISS 
ovulation from ovarian folliclePIEA IMP ISS 
regulation of transcription, DNA-dependentPIEA RCA ISS IEA 
negative regulation of transcriptionPIEA IDA ISS 
multicellular organismal developmentPIEA IEA 
biological_processPND 
transcriptionPIEA IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (11)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn
endocrine/exocrine gland phenotypeMPUn Un
immune system phenotypeMPUn
embryogenesis phenotypeMPUn
lethality-embryonic/perinatalMPUn Un
lethality-postnatalMPUn Un
nervous system phenotypeMPUn
vision/eye phenotypeMPUn
cardiovascular system phenotypeMPUn
reproductive system phenotypeMPUn Un
growth/size phenotypeMPUn Un

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Heart Failure, CongestiveDISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Caprolactam degradation (00930)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Nicotinate and nicotinamide metabolism (00760)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway