| IPI00016802 - SIRT1, NAD-DEPENDENT DEACETYLASE SIRTUIN-1. | |
|---|---|
| Uniprot Accession: Q96EB6 | |
| Uniprot ID: SIRT1_HUMAN | |
| Mapping: Chr 10, 69314433 - 69348153 | |
| Entrez Gene: 23411 | |
| Entrez MapView: |
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| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_14474) |
|---|
| Rat: Sirt1_predicted, SIMILAR TO NAD-DEPENDENT DEACETYLASE SIRTUIN-1. |
| Mouse: Sirt1, NAD-DEPENDENT DEACETYLASE SIRTUIN-1. |
| Rat: Sirt1_predicted, SIMILAR TO NAD-DEPENDENT DEACETYLASE SIRTUIN-1. |
| Rat: Sirt1_predicted, PROTEIN. |
| Human: SIRT1, NAD-DEPENDENT DEACETYLASE SIRTUIN-1. |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| nucleus | C | IEA | IDA IDA | ISS |
| chromatin silencing complex | C | IEA | RCA | ISS IEA |
| cellular_component | C | ND | ||
| hydrolase activity | F | IEA | IEA | |
| DNA binding | F | IEA | RCA | ISS IEA |
| NAD-dependent histone deacetylase activity | F | IEA | IDA | ISS |
| molecular_function | F | ND | ||
| metal ion binding | F | IEA | IEA | |
| NAD+ ADP-ribosyltransferase activity | F | TAS | ||
| transcription repressor activity | F | IEA | IDA | ISS |
| zinc ion binding | F | IEA | IEA | |
| response to nutrient levels | P | IEP | ||
| chromatin silencing | P | TAS | RCA | ISS IEA |
| histone deacetylation | P | IEA | IDA | ISS |
| cell differentiation | P | IEA | IEA | |
| apoptosis | P | IEA | IEA | |
| striated muscle development | P | IEA | IEA | |
| protein amino acid ADP-ribosylation | P | TAS | ||
| spermatogenesis | P | IEA | IMP | ISS |
| ovulation from ovarian follicle | P | IEA | IMP | ISS |
| regulation of transcription, DNA-dependent | P | IEA | RCA | ISS IEA |
| negative regulation of transcription | P | IEA | IDA | ISS |
| multicellular organismal development | P | IEA | IEA | |
| biological_process | P | ND | ||
| transcription | P | IEA | IEA |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| cellular phenotype | MP | Un | ||
| endocrine/exocrine gland phenotype | MP | Un Un | ||
| immune system phenotype | MP | Un | ||
| embryogenesis phenotype | MP | Un | ||
| lethality-embryonic/perinatal | MP | Un Un | ||
| lethality-postnatal | MP | Un Un | ||
| nervous system phenotype | MP | Un | ||
| vision/eye phenotype | MP | Un | ||
| cardiovascular system phenotype | MP | Un | ||
| reproductive system phenotype | MP | Un Un | ||
| growth/size phenotype | MP | Un Un |
| DO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Heart Failure, Congestive | D | ISS |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| Caprolactam degradation (00930) | Present in KEGG pathway | Present in KEGG pathway | Not present in KEGG pathway |
| Nicotinate and nicotinamide metabolism (00760) | Present in KEGG pathway | Present in KEGG pathway | Not present in KEGG pathway |