IpiRecord: IPI00017603

IPI00017603 - F8, COAGULATION FACTOR VIII PRECURSOR.
Uniprot Accession: Q9UMZ8
Uniprot ID: Q9UMZ8_HUMAN
Mapping: Chr X, 153717263 - 153904192
Entrez Gene: 2157
Entrez MapView:
+All IPI Database Cross References UniProtKB/Swiss-Prot: P00451 UniProtKB/Swiss-Prot: FA8_HUMAN Vega: OTTHUMP00000024269 ENSEMBL_HAVANA: ENSP00000327895 ENSEMBL_HAVANA: ENSG00000185010 REFSEQ_REVIEWED: NP_000123 REFSEQ_REVIEWED: GI:4503647 UniProtKB/TrEMBL: A0FJ18 UniProtKB/TrEMBL: A0FJ18_HUMAN UniProtKB/TrEMBL: A0FJ19 UniProtKB/TrEMBL: A0FJ19_HUMAN UniProtKB/TrEMBL: A0FJ20 UniProtKB/TrEMBL: A0FJ20_HUMAN UniProtKB/TrEMBL: A5JQJ5 UniProtKB/TrEMBL: A5JQJ5_HUMAN UniProtKB/TrEMBL: A5JQJ8 UniProtKB/TrEMBL: A5JQJ8_HUMAN UniProtKB/TrEMBL: Q003U9 UniProtKB/TrEMBL: Q003U9_HUMAN UniProtKB/TrEMBL: Q003V0 UniProtKB/TrEMBL: Q003V0_HUMAN UniProtKB/TrEMBL: Q003V2 UniProtKB/TrEMBL: Q003V2_HUMAN UniProtKB/TrEMBL: Q003V3 UniProtKB/TrEMBL: Q003V3_HUMAN UniProtKB/TrEMBL: Q003V4 UniProtKB/TrEMBL: Q003V4_HUMAN UniProtKB/TrEMBL: Q003V5 UniProtKB/TrEMBL: Q003V5_HUMAN UniProtKB/TrEMBL: Q003V6 UniProtKB/TrEMBL: Q003V6_HUMAN UniProtKB/TrEMBL: Q003V7 UniProtKB/TrEMBL: Q003V7_HUMAN UniProtKB/TrEMBL: Q003V8 UniProtKB/TrEMBL: Q003V8_HUMAN UniProtKB/TrEMBL: Q003V9 UniProtKB/TrEMBL: Q003V9_HUMAN UniProtKB/TrEMBL: Q003W0 UniProtKB/TrEMBL: Q003W0_HUMAN UniProtKB/TrEMBL: Q003W2 UniProtKB/TrEMBL: Q003W2_HUMAN UniProtKB/TrEMBL: Q2VF45 UniProtKB/TrEMBL: Q2VF45_HUMAN UniProtKB/TrEMBL: Q5HY69 UniProtKB/TrEMBL: Q5HY69_HUMAN UniProtKB/TrEMBL: Q71UI6 UniProtKB/TrEMBL: Q71UI6_HUMAN UniProtKB/TrEMBL: Q9UMZ8 UniProtKB/TrEMBL: Q9UMZ8_HUMAN ENSEMBL: ENSP00000353393 ENSEMBL: ENSG00000185010 H-InvDB: HIT000194302 UniParc: UPI000012A416 HGNC: 3546 Entrez Gene: 2157 UniGene: Hs.632836 UniGene: Hs.654450 CCDS: CCDS35457.1 trome: HTR011072 EPD: EP14077 UTRdb: BB004919 UTRdb: BB005091 UTRdb: BB005092 UTRdb: BB005093 UTRdb: BB282010 UTRdb: BB287447 UTRdb: BB385616 UTRdb: BB399216 UTRdb: CC009272 RZPD: Hs.632836 CleanEx: HS_F8 InterPro: IPR000421 InterPro: IPR001117 InterPro: IPR011706 InterPro: IPR011707 InterPro: IPR002355 InterPro: IPR008972 InterPro: IPR014707 InterPro: IPR008979 Pfam: PF00394 Pfam: PF07731 Pfam: PF07732 Pfam: PF00754 SMART: SM00231 PROSITE: PS01285 PROSITE: PS01286 PROSITE: PS50022 PROSITE: PS00079 SUPERFAMILY: SSF49503 SUPERFAMILY: SSF49785 PANTHER: PTHR10127:SF50 GENE3D: G3DSA:2.60.40.420

IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_13429)
Rat: F8, FACTOR VIII.
Mouse: F8, COAGULATION FACTOR VIII PRECURSOR.
Mouse: F8, COAGULATION FACTOR VIII.
Human: F8, COAGULATION FACTOR VIII ISOFORM B PRECURSOR.
Human: F8, COAGULATION FACTOR VIII PRECURSOR.
Human: F8, COAGULATION FACTOR VIII, PROCOAGULANT COMPONENT.
Human: F8, COAGULATION FACTOR VIII, PROCOAGULANT COMPONENT.

Annotations for F8 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
extracellular space	C		RCA	ISS IDA
extracellular region	C	NAS
calcium ion binding	F	IEA	IEA	IEA
metal ion binding	F		IEA
protein binding	F	IPI
copper ion binding	F	IEA	IEA	IEA
oxidoreductase activity	F	IEA	IEA	IEA
acute-phase response	P	IEA	IEA
cell adhesion	P	IEA	IEA	IEA
blood coagulation, intrinsic pathway	P			IMP
blood coagulation	P	TAS	IEA IEA	IEA ISS

Cellular Component

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Phenotype (2)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
homeostasis/metabolism phenotype	MP		Un
normal phenotype	MP		Un

Disease (4)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Rat
Hemophilia A	D	ISS
Venous Thrombosis	D	ISS
Cerebrovascular Accident	D	ISS
Thromboembolism	D	ISS

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
coagulation cascade pathway	W			IMP

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Complement and coagulation cascades (04610)	Present in KEGG pathway	Present in KEGG pathway	Not present in KEGG pathway