IpiRecord: IPI00020097

IPI00020097 - PPARA, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA.
Uniprot Accession: Q6I9S0
Uniprot ID: Q6I9S0_HUMAN
Mapping: Chr 22, 44925163 - 45018317
Entrez Gene: 5465
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7344)
Rat: Ppara, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA.
Mouse: Ppara, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA.
Human: PPARA, PPARA PROTEIN.
Human: PPARA, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA.
Human: PPARA, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA.
Human: PPARA, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (FRAGMENT).

Annotations for PPARA and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
nucleusCTAS IEA TAS ISS ISS IDA IEA 
receptor activityFIEA IDA ISS 
metal ion bindingFIEA IEA IEA 
steroid hormone receptor activityFIEA TAS TAS ISS IEA 
transcription factor activityFIEA IMP IEA 
protein bindingFIPI IPI ISS IPI ISS ISS IPI IEA 
protein heterodimerization activityFTAS 
protein domain specific bindingFIDA 
DNA bindingFIDA IDA ISS 
ligand-regulated transcription factor activityFIDA 
transcription activator activityFIEA IDA ISS IMP IEA 
sequence-specific DNA bindingFIEA IDA IEA 
zinc ion bindingFIEA IEA IEA IEA 
ligand-dependent nuclear receptor activityFIEA IEA IMP IMP 
glucose metabolic processPTAS ISS 
lipid metabolic processPTAS TAS TAS ISS ISS 
fatty acid metabolic processPIMP TAS ISS ISS IMP IMP IMP 
positive regulation of transcriptionPIEA IMP ISS IEA 
response to hypoxiaPIDA 
fatty acid transportPTAS ISS 
transcription from RNA polymerase II promoterPTAS ISS 
response to insulin stimulusPIMP 
lipoprotein metabolic processPIMP 
transcriptionPIEA IEA IEA 
regulation of transcription, DNA-dependentPIEA TAS IDA ISS IEA 
negative regulation of blood pressurePIMP 
positive regulation of fatty acid beta-oxidationPTAS ISS 
epidermis developmentPIEA IMP ISS IEA 
regulation of fatty acid metabolic processPIEA IMP TAS ISS IEA 
positive regulation of transcription from RNA polymerase II promoterPIEA IDA ISS IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (9)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
skin/coat/nails phenotypeMPUn
adipose tissue phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
immune system phenotypeMPUn
muscle phenotypeMPUn
cardiovascular system phenotypeMPUn
growth/size phenotypeMPUn
life span-post-weaning/agingMPUn
liver/biliary system phenotypeMPUn

Disease (4)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Hypertrophy, Left VentricularDISS
Lipid Metabolism, Inborn ErrorsDISS
Coronary ArteriosclerosisDISS
HypertensionDIED

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
PPAR signaling pathway (03320)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Adipocytokine signaling pathway (04920)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway