IpiRecord: IPI00020985

IPI00020985 - EP300, HISTONE ACETYLTRANSFERASE P300.
Uniprot Accession: Q7Z6C1
Uniprot ID: Q7Z6C1_HUMAN
Mapping: Chr 22, 39817736 - 39905472
Entrez Gene: 2033
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7254)
Rat: Ep300, SIMILAR TO E1A BINDING PROTEIN P300.
Mouse: Ep300, E1A BINDING PROTEIN P300.
Mouse: Ep300, SEQUENCE.
Rat: Ep300, E1A-BINDING PROTEIN.
Human: EP300, HISTONE ACETYLTRANSFERASE P300.

Annotations for EP300 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
nucleusCIDA IDA IDA IEA ISS 
transcription factor complexCIDA ISS IC 
histone acetyltransferase complexCIEA IDA ISS 
histone acetyltransferase activityFIDA IDA ISS 
acetyltransferase activityFIMP 
transcription activator activityFIDA IDA ISS IMP 
transcription factor activityFTAS IMP 
peroxisome proliferator activated receptor bindingFIDA 
metal ion bindingFIEA 
protein bindingFIPI IPI IPI ISS 
transferase activityFIEA 
protein C-terminus bindingFTAS 
transcription cofactor activityFIEA 
transcription coactivator activityFIDA IEP IDA IDA ISS 
DNA bindingFIDA IDA ISS 
transcription factor bindingFIPI 
zinc ion bindingFIEA IEA 
homeostatic processPTAS 
positive regulation of transcription factor activityPIDA 
N-terminal peptidyl-lysine acetylationPIDA 
response to hypoxiaPIDA 
striated muscle developmentPIEA IMP ISS 
regulation of transcriptionPIDA ISS 
apoptosisPIMP 
nervous system developmentPTAS 
lung developmentPIEA IMP ISS 
heart developmentPIEA IMP ISS 
cell cyclePIEA 
regulation of transcription, DNA-dependentPIDA IEA ISS 
organ morphogenesisPIEA IMP ISS 
positive regulation of transcription, DNA-dependentPIDA ISS 
positive regulation of transcription from RNA polymerase II promoterPIEA IGI IMP 
histone acetylationPIEA 
signal transductionPNAS 
somitogenesisPIEA IGI ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (16)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn
craniofacial phenotypeMPUn Un
growth/size phenotypeMPUn Un Un
immune system phenotypeMPUn Un
embryogenesis phenotypeMPUn
lethality-embryonic/perinatalMPUn Un Un
lethality-postnatalMPUn Un
muscle phenotypeMPUn Un
hematopoietic system phenotypeMPUn Un Un
respiratory system phenotypeMPUn
vision/eye phenotypeMPUn
tumorigenesisMPUn Un Un
digestive/alimentary phenotypeMPUn
cardiovascular system phenotypeMPUn Un
nervous system phenotypeMPUn
cardiac hypertrophyNIED

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Rubinstein-Taybi SyndromeDISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (9)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
TGF-beta signaling pathway (04350)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Cell cycle (04110)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Adherens junction (04520)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Jak-STAT signaling pathway (04630)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Wnt signaling pathway (04310)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Huntington's disease (05040)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Long-term potentiation (04720)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Notch signaling pathway (04330)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Neurodegenerative Disorders (01510)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway