| IPI00021770 - HMGCR, ISOFORM 1 OF 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE. | |
|---|---|
| Uniprot Accession: P04035-1 | |
| Uniprot ID: HMDH_HUMAN | |
| Mapping: Chr 5, 74668790 - 74693685 | |
| Entrez Gene: 3156 | |
| Entrez MapView: |
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| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_2084) |
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| Rat: Hmgcr, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE. |
| Mouse: Hmgcr, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE. |
| Human: HMGCR, ISOFORM 1 OF 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE. |
| Human: HMGCR, ISOFORM 2 OF 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE. |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| microsome | C | IDA IDA | IDA ISS | |
| membrane fraction | C | ISS | ||
| membrane | C | IEA | IEA | |
| integral to membrane | C | IEA IEA | IEA | |
| endoplasmic reticulum | C | IEA | IEA | |
| endoplasmic reticulum membrane | C | IEA | IEA ISS | |
| peroxisome | C | IEA | ||
| hydroxymethylglutaryl-CoA reductase activity | F | IDA | ||
| oxidoreductase activity | F | IEA | IEA | |
| hydroxymethylglutaryl-CoA reductase (NADPH) activity | F | IDA IDA IDA IDA IDA IDA IDA IDA | IEA ISS | |
| protein homodimerization activity | F | IDA | ||
| sterol biosynthetic process | P | IEA | ||
| negative regulation of MAPK activity | P | IGI | ||
| gonad development | P | ISS | ||
| embryonic development | P | IMP | IEA ISS | |
| lipid metabolic process | P | IEA | IEA | |
| visual learning | P | IGI | ||
| lipid biosynthetic process | P | IEA | ||
| farnesyl diphosphate biosynthetic process, mevalonate pathway | P | TAS | ||
| biosynthetic process | P | IEA | ||
| cholesterol biosynthetic process | P | IDA IDA IDA | IEA IDA ISS | |
| germ cell migration | P | ISS | ||
| steroid biosynthetic process | P | IEA |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| lethality-embryonic/perinatal | MP | Un | ||
| normal phenotype | MP | Un |
| PW Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| steroid biosynthetic pathway | W | IEA |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| Biosynthesis of steroids (00100) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |