IpiRecord: IPI00022477

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
cytosol	C	IDA	IDA	IDA ISS
lipopolysaccharide receptor complex	C	IDA		ISS
immunological synapse	C		IDA
cytoplasm	C	IDA IDA IDA IDA	IDA ISS	ISS ISS
lysosome	C	IDA		ISS
intracellular	C	IEA	IEA	IEA
nucleus	C	IDA		ISS
T cell receptor complex	C	IDA		ISS
protein complex	C			ISS
perinuclear region of cytoplasm	C	IDA		ISS
lipid raft	C	IEA	IDA	ISS
CBM complex	C	NAS
protein heterodimerization activity	F		ISS
protein homodimerization activity	F		ISS
caspase activator activity	F		ISS
molecular_function	F			ND
transcription coactivator activity	F	IDA		ISS
ubiquitin binding	F	IDA		ISS
protein binding	F		IPI IPI
protein C-terminus binding	F	IPI		ISS
protein kinase B binding	F	IPI		ISS
protein self-association	F	IPI		ISS
NF-kappaB binding	F	IDA		ISS
ubiquitin protein ligase binding	F	IPI		ISS
kinase activator activity	F	IDA		ISS
positive regulation of T cell activation	P	IEA	IMP
cellular defense response	P	IEA	IMP	ISS
negative regulation of progression through cell cycle	P	IEA	IEA	IEA
activation of JNK activity	P		ISS
immunoglobulin mediated immune response	P	IEA	IMP	ISS
T cell receptor signaling pathway	P			ISS
innate immune response	P	IEP		ISS
activation of NF-kappaB transcription factor	P	IDA IDA	ISS IMP ISS ISS	ISS
I-kappaB kinase/NF-kappaB cascade	P	IEA	IMP ISS	ISS
apoptosis	P		IMP IDA	IDA ISS
cell death	P	IDA		ISS
response to chemical stimulus	P	IDA		ISS
regulation of apoptosis	P	IEA	IEA	IEA
interleukin-6 biosynthetic process	P	NAS
protein homooligomerization	P	TAS ISS	IMP	ISS
negative regulation of mature B cell apoptosis	P	IDA		ISS
caspase activation	P		ISS
response to fungus	P	IEA	IMP
cell cycle	P	IEA	IEA	IEA
induction of apoptosis	P		ISS ISS	IDA
toll-like receptor signaling pathway	P	IC
neural tube closure	P	ISS	IMP	ISS
response to molecule of bacterial origin	P	IEP		ISS
adaptive immune response	P	TAS
regulation of T cell receptor signaling pathway	P	IEA	IMP
mast cell activation	P		NAS
positive regulation of I-kappaB kinase/NF-kappaB cascade	P	IEP		ISS
lymphotoxin A biosynthetic process	P	NAS
positive regulation of interleukin-8 biosynthetic process	P	IMP		ISS
positive regulation of mast cell cytokine production	P	NAS
positive regulation of transcription, DNA-dependent	P	IDA		ISS
positive regulation of phosphorylation	P	IDA		ISS
positive regulation of protein ubiquitination	P	IDA		ISS

Cellular Component

Biological Process

Molecular Function

Phenotype (5)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
cellular phenotype	MP		Un
immune system phenotype	MP		Un Un
lethality-embryonic/perinatal	MP		Un Un
nervous system phenotype	MP		Un Un
hematopoietic system phenotype	MP		Un Un

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
T cell receptor signaling pathway (04660)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
B cell receptor signaling pathway (04662)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway