IpiRecord: IPI00023664

IPI00023664 - CHEK1, SERINE/THREONINE-PROTEIN KINASE CHK1.
Uniprot Accession: Q6W8P8
Uniprot ID: Q6W8P8_HUMAN
Mapping: Chr 11, 125001547 - 125030847
Entrez Gene: 1111
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7773)
Rat: Chek1, ISOFORM 1 OF SERINE/THREONINE-PROTEIN KINASE CHK1.
Mouse: Chek1, ISOFORM 2 OF SERINE/THREONINE-PROTEIN KINASE CHK1.
Mouse: Chek1, ISOFORM 1 OF SERINE/THREONINE-PROTEIN KINASE CHK1.
Rat: Chek1, ISOFORM 2 OF SERINE/THREONINE-PROTEIN KINASE CHK1.
Human: CHEK1, SERINE/THREONINE-PROTEIN KINASE CHK1.

Annotations for CHEK1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
nucleusCIEA IDA ISS 
cytoplasmCIEA IEA 
condensed nuclear chromosomeCTAS ISS 
replication forkCIEA IDA ISS 
protein kinase activityFIMP ISS ISS 
protein-tyrosine kinase activityFISS 
protein serine/threonine kinase activityFIEA IEA IEA 
kinase activityFIEA 
ATP bindingFIEA IEA IEA 
protein bindingFIPI IPI IPI IPI IPI ISS 
nucleotide bindingFIEA IEA 
transferase activityFIEA IEA 
negative regulation of cell proliferationPTAS ISS 
cell cycle checkpointPISS 
protein amino acid phosphorylationPIEA IDA ISS ISS 
cell cyclePIEA IEA 
DNA repairPIEA IDA ISS 
gamete generationPTAS ISS 
regulation of cyclin-dependent protein kinase activityPTAS ISS 
DNA damage checkpointPTAS IDA IMP ISS ISS 
meiotic recombinationPTAS ISS 
response to DNA damage stimulusPIDA IDA ISS 
G2/M transition of mitotic cell cyclePIEA IMP ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (6)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn Un Un
endocrine/exocrine gland phenotypeMPUn
embryogenesis phenotypeMPUn Un
lethality-embryonic/perinatalMPUn Un
tumorigenesisMPUn
reproductive system phenotypeMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (1)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Cell cycle (04110)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway