IpiRecord: IPI00025803

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
plasma membrane	C			ISS ISS IDA
membrane	C	IEA
cytosol	C			IDA
integral to membrane	C	IEA		IEA
endosome	C			IDA
integral to plasma membrane	C			ISS
protein binding	F			ISS IPI
transmembrane receptor protein tyrosine kinase activity	F	IEA
3-phosphoinositide-dependent protein kinase binding	F			IDA
receptor activity	F	IEA		ISS IEA
insulin receptor activity	F			ISS IMP IDA IDA IMP
ATP binding	F	IEA		IEA
receptor signaling protein tyrosine kinase activity	F			ISS
transmembrane receptor protein tyrosine kinase signaling protein activity	F			ISS
protein phosphatase binding	F			IMP
SH2 domain binding	F			ISS
insulin binding	F			ISS IMP IDA IMP
transferase activity	F	IEA		IEA
insulin receptor substrate binding	F			ISS IMP
PTB domain binding	F			ISS
phosphoinositide 3-kinase binding	F			ISS
nucleotide binding	F	IEA		IEA
protein amino acid phosphorylation	P	IEA		IDA
generation of precursor metabolites and energy	P			ISS
transmembrane receptor protein tyrosine kinase signaling pathway	P	IEA
peptidyl-tyrosine phosphorylation	P			IMP
carbohydrate metabolic process	P			ISS
signal transduction	P			ISS
protein heterotetramerization	P			ISS
insulin receptor signaling pathway	P			ISS ISS IMP IDA
organ morphogenesis	P			ISS
multicellular organismal development	P			ISS
male sex determination	P			ISS
protein amino acid autophosphorylation	P			ISS IMP IDA

Cellular Component

Biological Process

Molecular Function

Phenotype (9)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
postnatal growth retardation	N			ISS
cardiac hypertrophy	N			ISS
postnatal lethality	N			ISS
increased insulin secretion	N			ISS
decreased adipose tissue amount	N			ISS
impaired glucose tolerance	N			ISS
increased circulating leptin level	N			ISS
insulin resistance	N			ISS
increased circulating insulin level	N			ISS

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (2)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
insulin signaling pathway	W			IDAIMPISS
Alzheimer disease pathway	W			IEA

KEGG Pathway (4)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Adherens junction (04520)	Present in KEGG pathway	Not present in KEGG pathway	Present in KEGG pathway
Type II diabetes mellitus (04930)	Present in KEGG pathway	Not present in KEGG pathway	Present in KEGG pathway
Dentatorubropallidoluysian atrophy (DRPLA) (05050)	Present in KEGG pathway	Not present in KEGG pathway	Present in KEGG pathway
Insulin signaling pathway (04910)	Present in KEGG pathway	Not present in KEGG pathway	Present in KEGG pathway