IpiRecord: IPI00030746

IPI00030746 - CHEK2, ISOFORM 12 OF SERINE/THREONINE-PROTEIN KINASE CHK2.
Uniprot Accession: O96017-12
Uniprot ID: CHK2_HUMAN
Mapping: Chr 22, 27413731 - 27467822
Entrez Gene: 11200
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_11041)
Rat: Chek2, CHECKPOINT KINASE CHK2.
Mouse: Chek2, SERINE/THREONINE-PROTEIN KINASE CHK2.
Human: CHEK2, ISOFORM 1 OF SERINE/THREONINE-PROTEIN KINASE CHK2.
Human: CHEK2, ISOFORM 12 OF SERINE/THREONINE-PROTEIN KINASE CHK2.
Human: CHEK2, ISOFORM 3 OF SERINE/THREONINE-PROTEIN KINASE CHK2.
Human: CHEK2, ISOFORM 6 OF SERINE/THREONINE-PROTEIN KINASE CHK2.
Human: CHEK2, ISOFORM 9 OF SERINE/THREONINE-PROTEIN KINASE CHK2.
Human: CHEK2, ISOFORM 11 OF SERINE/THREONINE-PROTEIN KINASE CHK2.
Human: CHEK2, ISOFORM 8 OF SERINE/THREONINE-PROTEIN KINASE CHK2.
Human: CHEK2, ISOFORM 7 OF SERINE/THREONINE-PROTEIN KINASE CHK2.
Human: CHEK2, ISOFORM 4 OF SERINE/THREONINE-PROTEIN KINASE CHK2.
Human: CHEK2, ISOFORM 5 OF SERINE/THREONINE-PROTEIN KINASE CHK2.
Human: CHEK2, ISOFORM 2 OF SERINE/THREONINE-PROTEIN KINASE CHK2.
Human: CHEK2, ISOFORM 10 OF SERINE/THREONINE-PROTEIN KINASE CHK2.

Annotations for CHEK2 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cellular_componentCND 
nucleusCIEA ISS 
protein serine/threonine kinase activityFIEA IEA IDA ISS IEA 
nucleotide bindingFIEA 
ATP bindingFIEA IEA IEA 
protein bindingFISS 
protein-tyrosine kinase activityFISS 
transferase activityFIEA 
magnesium ion bindingFIEA 
kinase activityFIEA IDA 
metal ion bindingFIEA 
protein kinase activityFIEA 
cell cyclePIEA 
protein amino acid phosphorylationPIEA IEA 
DNA damage response, signal transductionPIDA ISS 
DNA damage checkpointPIMP ISS 
response to gamma radiationPIDA 
response to DNA damage stimulusPISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (5)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn Un
immune system phenotypeMPUn
tumorigenesisMPUn
hematopoietic system phenotypeMPUn
life span-post-weaning/agingMPUn Un

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Breast NeoplasmsDISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Cell cycle (04110)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway