IpiRecord: IPI00031171

IPI00031171 - IL6R, ISOFORM 1 OF INTERLEUKIN-6 RECEPTOR ALPHA CHAIN PRECURSOR.
Uniprot Accession: A0N0L5
Uniprot ID: A0N0L5_HUMAN
Mapping: Chr 1, 152644293 - 152708550
Entrez Gene: 3570
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_2574)
Rat: Il6ra, INTERLEUKIN-6 RECEPTOR ALPHA CHAIN PRECURSOR.
Mouse: Il6ra, INTERLEUKIN-6 RECEPTOR ALPHA CHAIN PRECURSOR.
Rat: Il6ra, INTERLEUKIN 6 RECEPTOR, ALPHA.
Human: IL6R, ISOFORM 1 OF INTERLEUKIN-6 RECEPTOR ALPHA CHAIN PRECURSOR.
Human: IL6R, ISOFORM 2 OF INTERLEUKIN-6 RECEPTOR ALPHA CHAIN PRECURSOR.

Annotations for IL6R and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
integral to plasma membraneCIEA 
membraneCIEA IEA IEA 
extracellular spaceCIDA 
integral to membraneCRCA ISS IEA 
interleukin-6 receptor complexCISS 
extracellular regionCISS 
interleukin receptor activityFIEA 
hematopoietin/interferon-class (D200-domain) cytokine receptor activityFIEA IEA 
enzyme bindingFISS 
receptor activityFIEA IEA 
interleukin-6 receptor activityFISS IMP 
cell surface receptor linked signal transductionPIEA ISS 
response to lipopolysaccharidePIEP 
response to gamma radiationPIEP 
response to cAMPPIEP 
cell proliferationPISS 
immune responsePISS 
response to ethanolPIEP 
response to peptide hormone stimulusPIEP 
response to glucocorticoid stimulusPIEP 
multicellular organismal developmentPISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (0)

There are no Mammalian Phenotype Ontology annotations for this protein in the database

Disease (10)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Acute-Phase ReactionDIEP
ObesityDISSISSISS
SeizuresDIEP
Metabolic Syndrome XDISS
Myocardial InfarctionDIEP
Insulin ResistanceDISS
OrchitisDIEP
Myocardial Reperfusion InjuryDISS
Heart Failure, CongestiveDIEP
HypertensionDISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (3)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Jak-STAT signaling pathway (04630)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Hematopoietic cell lineage (04640)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cytokine-cytokine receptor interaction (04060)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway