IpiRecord: IPI00031386

IPI00031386 - PIK3CA, ISOFORM.
Uniprot Accession: Q4LE51
Uniprot ID: Q4LE51_HUMAN
Mapping: Chr 3, 180349005 - 180435189
Entrez Gene: 5290
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_15702)
Human: PIK3CA, ISOFORM.
Mouse: Pik3ca, ISOFORM.
Mouse: Pik3ca, 110 KDA PROTEIN.
Human: PIK3CA, HBV PRES1-TRANSACTIVATED PROTEIN 3 BINDING PROTEIN 1.

Annotations for PIK3CA and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
phosphoinositide 3-kinase complexCIEA IPI 
lamellipodiumCIEA IDA 
transferase activityFIEA IEA 
kinase activityFIEA 
1-phosphatidylinositol-3-kinase activityFIDA IDA 
phosphotransferase activity, alcohol group as acceptorFIEA 
inositol or phosphatidylinositol kinase activityFIEA IEA 
insulin receptor substrate bindingFIEA IPI 
phosphatidylinositol-4,5-bisphosphate 3-kinase activityFIEA IEA 
regulation of body sizePIEA IMP 
protein kinase B signaling cascadePIEA IMP 
glucose metabolic processPIEA IMP 
phosphoinositide-mediated signalingPIEA IEA 
protein amino acid phosphorylationPIEA IDA 
negative regulation of apoptosisPIDA 
anti-apoptosisPIEA IMP 
signal transductionPIEA IEA 
phosphoinositide phosphorylationPIEA IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (16)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
adipose tissue phenotypeMPUn
cellular phenotypeMPUn Un
behavior/neurological phenotypeMPUn
endocrine/exocrine gland phenotypeMPUn
homeostasis/metabolism phenotypeMPUn Un Un
embryogenesis phenotypeMPUn
immune system phenotypeMPUn
lethality-embryonic/perinatalMPUn Un Un
lethality-postnatalMPUn
muscle phenotypeMPUn
nervous system phenotypeMPUn
tumorigenesisMPUn
cardiovascular system phenotypeMPUn
digestive/alimentary phenotypeMPUn
no phenotypic analysisMPUn
growth/size phenotypeMPUn Un Un

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (20)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Glioma (05214)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
T cell receptor signaling pathway (04660)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Chronic myeloid leukemia (05220)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
B cell receptor signaling pathway (04662)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
mTOR signaling pathway (04150)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Toll-like receptor signaling pathway (04620)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Fc epsilon RI signaling pathway (04664)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Apoptosis (04210)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Jak-STAT signaling pathway (04630)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
VEGF signaling pathway (04370)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Type II diabetes mellitus (04930)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Leukocyte transendothelial migration (04670)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Colorectal cancer (05210)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Regulation of actin cytoskeleton (04810)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Inositol phosphate metabolism (00562)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Pancreatic cancer (05212)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Insulin signaling pathway (04910)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Natural killer cell mediated cytotoxicity (04650)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Focal adhesion (04510)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Phosphatidylinositol signaling system (04070)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway