IpiRecord: IPI00059926

IPI00059926 - CDK4, CDK4 PROTEIN.
Uniprot Accession: Q96BE9
Uniprot ID: Q96BE9_HUMAN
Mapping: Chr 12, 56428272 - 56432431
Entrez Gene: 1019
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7026)
Rat: Cdk4, CELL DIVISION PROTEIN KINASE 4.
Mouse: Cdk4, CELL DIVISION PROTEIN KINASE 4.
Human: CDK4, CELL DIVISION PROTEIN KINASE 4.
Human: CDK4, CDK4 PROTEIN.
Human: CDK4, 17 KDA PROTEIN.
Human: CDK4, 5 KDA PROTEIN.
Human: CDK4, 6 KDA PROTEIN.
Human: CDK4, 3 KDA PROTEIN.

Annotations for CDK4 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cyclin-dependent protein kinase holoenzyme complexCIPI ISS IEA 
transcription factor complexCIDA ISS IEA 
nucleusCIDA IDA IDA IDA ISS ISS IEA 
protein serine/threonine kinase activityFIEA IEA IEA 
protein bindingFIPI IPI IPI IPI IPI IPI IPI IPI IPI IPI IPI IPI IPI ISS ISS IDA IEA 
kinase activityFIDA ISS 
transferase activityFIEA IEA IEA 
ATP bindingFIEA IEA IEA IEA 
protein kinase activityFIEA IDA IDA ISS 
cyclin-dependent protein kinase activityFTAS IDA IDA ISS ISS IDA 
nucleotide bindingFIEA IEA IEA 
circadian rhythmPIEP 
G1/S transition of mitotic cell cyclePTAS ISS 
regulation of progression through cell cyclePTAS IDA TAS ISS ISS 
positive regulation of protein biosynthetic processPIMP 
positive regulation of progression through cell cyclePTAS 
cell proliferationPTAS ISS 
protein amino acid phosphorylationPIEA IDA IDA ISS IEA 
cell cyclePIEA IEA IEA IEA 
regulation of cell proliferationPIMP ISS IEA 
signal transductionPIDA ISS IEA 
positive regulation of cell sizePIMP 
cell divisionPIEA IEA IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (22)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
skin/coat/nails phenotypeMPUn
cellular phenotypeMPUn Un
behavior/neurological phenotypeMPUn
endocrine/exocrine gland phenotypeMPUn Un
homeostasis/metabolism phenotypeMPUn Un
growth/size phenotypeMPUn Un
immune system phenotypeMPUn
embryogenesis phenotypeMPUn Un
lethality-embryonic/perinatalMPUn Un
muscle phenotypeMPUn
lethality-postnatalMPUn Un
hematopoietic system phenotypeMPUn Un
nervous system phenotypeMPUn
liver/biliary system phenotypeMPUn Un
vision/eye phenotypeMPUn
reproductive system phenotypeMPUn Un
cardiovascular system phenotypeMPUn
digestive/alimentary phenotypeMPUn Un
renal/urinary system phenotypeMPUn Un
tumorigenesisNUn IED
Increased Cell SizeNIED
cardiac hypertrophyNIED

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (2)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
S phaseWIEA
G1 phaseWIEA

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Glioma (05214)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
T cell receptor signaling pathway (04660)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Chronic myeloid leukemia (05220)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cell cycle (04110)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Tight junction (04530)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pancreatic cancer (05212)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway