IpiRecord: IPI00071059

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
mitochondrial permeability transition pore complex	C	IDA
endoplasmic reticulum membrane	C	IDA
cytosol	C	IDA	IDA IDA IDA	ISS IDA
membrane	C	IEA	IEA	IEA
integral to membrane	C	IEA	ISS	IEA
endoplasmic reticulum	C	IDA
cellular_component	C	ND
mitochondrial outer membrane	C		IDA IDA IDA	ISS IDA
soluble fraction	C		IDA
mitochondrial membrane	C		IDA	IMP
cytosolic part	C		IDA
cytoplasm	C	IEA	IDA IDA IDA IDA	IMP ISS IDA IDA
mitochondrion	C	IDA	IDA IDA	ISS IDA IDA IDA
protein binding	F	ISS ISS IPI ISS	IPI	ISS IPI IPI
molecular_function	F	ND
heat shock protein binding	F			IPI
lipid binding	F	IDA
BH3 domain binding	F	IPI IPI	IPI
protein heterodimerization activity	F	IPI	IPI	ISS IPI
protein homodimerization activity	F	IDA IPI		ISS
establishment and/or maintenance of transmembrane electrochemical gradient	P	IDA
nervous system development	P		IMP	ISS
retinal cell programmed cell death	P		IMP	ISS
induction of retinal programmed cell death	P	IMP
mitochondrial fragmentation during apoptosis	P	IDA
regulation of protein heterodimerization	P	IPI
mitochondrial fusion	P	IDA	IGI IGI
negative regulation of neuron apoptosis	P		IDA
response to wounding	P		IMP	ISS
outer mitochondrial membrane organization and biogenesis	P			IDA
protein homooligomerization	P	IDA	IDA	ISS
positive regulation of apoptosis	P		IMP
DNA fragmentation during apoptosis	P	IMP
regulation of apoptosis	P	IEA	IEA	IEA
neuron apoptosis	P		IMP
negative regulation of progression through cell cycle	P	IEA
response to toxin	P	IDA	IMP
apoptotic mitochondrial changes	P	TAS	IDA	ISS
caspase activation via cytochrome c	P	IDA	IDA IMP	TAS ISS
induction of apoptosis by intracellular signals	P	IDA	IMP	ISS
T cell homeostatic proliferation	P		IMP
positive regulation of neuron apoptosis	P	IDA
regulation of mitochondrial membrane potential	P	IDA	IDA
apoptosis	P	IEA	IDA IDA	IEP ISS
transformed cell apoptosis	P	IMP
germ cell development	P	TAS
cell cycle	P	IEA
spermatogenesis	P		IMP IMP
protein insertion into mitochondrial membrane during induction of apoptosis	P		IMP	ISS
inner mitochondrial membrane organization and biogenesis	P			IDA
caspase activation	P	IDA	IMP
nuclear fragmentation during apoptosis	P	IMP	IDA	ISS
negative regulation of survival gene product activity	P	IDA TAS
regulation of protein homodimerization	P	IDA
induction of apoptosis	P	NAS IDA	IDA IMP	IMP ISS IMP
release of matrix enzymes from mitochondria	P	IDA
induction of apoptosis by extracellular signals	P	IDA TAS	IMP IMP	ISS
Sertoli cell proliferation	P		IGI
cleavage of lamin	P	IMP
B cell apoptosis	P	IDA IDA IEP
B cell homeostatic proliferation	P		IMP
negative regulation of fibroblast proliferation	P		IMP	ISS
cellular respiration	P			IDA
regulation of caspase activity	P		IMP	ISS
response to DNA damage stimulus	P		IMP IMP	ISS
release of cytochrome c from mitochondria	P	IDA IDA	IDA IDA IDA	IMP ISS

Cellular Component

Biological Process

Molecular Function

Phenotype (17)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
cellular phenotype	MP		Un Un
growth/size phenotype	MP		Un
behavior/neurological phenotype	MP		Un
endocrine/exocrine gland phenotype	MP		Un
immune system phenotype	MP		Un Un
lethality-embryonic/perinatal	MP		Un Un
skeleton phenotype	MP		Un Un
renal/urinary system phenotype	MP		Un Un
reproductive system phenotype	MP		Un
nervous system phenotype	MP		Un Un Un
hearing/vestibular/ear phenotype	MP		Un
limbs/digits/tail phenotype	MP		Un
hematopoietic system phenotype	MP		Un Un
life span-post-weaning/aging	MP		Un Un
dilated renal tubules	N			IED
abnormal renal tubule morphology	N			IED
glomerulosclerosis	N			IED

Disease (4)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
Leukemia, T-Cell, Acute	D			ISS
Nephritis, Interstitial	D			IED
Colorectal Neoplasms	D			ISS
Glomerulonephritis	D			IED

Pathway (3)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
intrinsic apoptotic pathway	W			ISS
programmed cell death pathway	W			IEA
amyotrophic lateral sclerosis disease pathway	W			IEA

KEGG Pathway (5)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Apoptosis (04210)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Amyotrophic lateral sclerosis (ALS) (05030)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Huntington's disease (05040)	Present in KEGG pathway	Not present in KEGG pathway	Not present in KEGG pathway
Colorectal cancer (05210)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Neurodegenerative Disorders (01510)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway