IPI report for IPI00103724

IpiRecord: IPI00103724

IPI00103724 - MDM2, ISOFORM MDM2-G OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.
Uniprot Accession: Q00987-10
Uniprot ID: MDM2_HUMAN
Mapping: Chr 12, 67488247 - 67520481
Entrez Gene: 4193
Entrez MapView:
+All IPI Database Cross References UniProtKB/Swiss-Prot: Q00987-10 UniProtKB/Swiss-Prot: MDM2_HUMAN Vega: OTTHUMP00000183489 ENSEMBL: ENSP00000258148 ENSEMBL: ENSG00000135679 UniParc: UPI0000D4876B HGNC: 6973 Entrez Gene: 4193 UniGene: Hs.567303 UTRdb: CC167316 UTRdb: CC168262 UTRdb: CC168263 UTRdb: CC168264 UTRdb: CC168265 RZPD: Hs.567303 InterPro: IPR003121 InterPro: IPR001876 InterPro: IPR001841 InterPro: IPR013083 Pfam: PF02201 Pfam: PF00641 SMART: SM00184 PROSITE: PS01358 PROSITE: PS50199 PROSITE: PS50089 GENE3D: G3DSA:1.10.245.10 GENE3D: G3DSA:3.30.40.10

IPI00103724 - MDM2, ISOFORM MDM2-G OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.

Uniprot Accession: Q00987-10

Uniprot ID: MDM2_HUMAN

Mapping: Chr 12, 67488247 - 67520481

Entrez Gene: 4193

Entrez MapView: Geneprod

+All IPI Database Cross References

IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7068)
Rat: Mdm2_predicted, SIMILAR TO TRANSFORMED MOUSE 3T3 CELL DOUBLE MINUTE 2.
Mouse: Mdm2, FULL INSERT SEQUENCE.
Mouse: Mdm2, ISOFORM MDM2-P90 OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.
Mouse: Mdm2, TRANSFORMED MOUSE 3T3 CELL DOUBLE MINUTE 2 TRANSCRIPT VARIANT.
Rat: Mdm2_predicted, SIMILAR TO TRANSFORMED MOUSE 3T3 CELL DOUBLE MINUTE 2.
Human: MDM2, MDM2 (FRAGMENT).
Human: MDM2, P53-BINDING PROTEIN.
Human: MDM2, ISOFORM MDM2-F OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.
Human: MDM2, ISOFORM MDM2-G OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.
Human: MDM2, MOUSE DOUBLE MINUTE 2 HOMOLOG ISOFORM MDM2D.
Human: MDM2, ISOFORM MDM2-A OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.
Human: MDM2, ISOFORM MDM2-A1 OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.
Human: MDM2, ISOFORM MDM2-B OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.
Human: MDM2, ISOFORM MDM2-ALPHA OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.
Human: MDM2, ISOFORM MDM2-C OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.
Human: MDM2, MOUSE DOUBLE MINUTE 2 HOMOLOG ISOFORM MDM2E.
Human: MDM2, HDM2-HD5 PROTEIN.
Human: MDM2, HDM2-HD2 PROTEIN.
Human: MDM2, P53 BINDING PROTEIN.
Human: MDM2, P53-BINDING PROTEIN.
Human: MDM2, MDM2 VARIANT FB30.
Human: MDM2, MDM2 VARIANT FB29.
Human: MDM2, MOUSE DOUBLE MINUTE 2 HOMOLOG ISOFORM MDM2B.
Human: MDM2, MDM2 PROTEIN.
Human: MDM2, MOUSE DOUBLE MINUTE 2 HOMOLOG ISOFORM MDM2A.
Human: MDM2, P53 BINDING PROTEIN.
Human: MDM2, P53 BINDING PROTEIN.
Human: MDM2, MOUSE DOUBLE MINUTE 2 HOMOLOG ISOFORM MDM2.
Human: MDM2, MDM2 VARIANT FB25.
Human: MDM2, MDM2 VARIANT FB55.
Human: MDM2, 9 KDA PROTEIN.
Human: MDM2, 26 KDA PROTEIN.
Human: MDM2, UNCHARACTERIZED PROTEIN MDM2.

IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7068)

Rat: Mdm2_predicted, SIMILAR TO TRANSFORMED MOUSE 3T3 CELL DOUBLE MINUTE 2.

Mouse: Mdm2, FULL INSERT SEQUENCE.

Mouse: Mdm2, ISOFORM MDM2-P90 OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.

Mouse: Mdm2, TRANSFORMED MOUSE 3T3 CELL DOUBLE MINUTE 2 TRANSCRIPT VARIANT.

Rat: Mdm2_predicted, SIMILAR TO TRANSFORMED MOUSE 3T3 CELL DOUBLE MINUTE 2.

Human: MDM2, MDM2 (FRAGMENT).

Human: MDM2, P53-BINDING PROTEIN.

Human: MDM2, ISOFORM MDM2-F OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.

Human: MDM2, ISOFORM MDM2-G OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.

Human: MDM2, MOUSE DOUBLE MINUTE 2 HOMOLOG ISOFORM MDM2D.

Human: MDM2, ISOFORM MDM2-A OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.

Human: MDM2, ISOFORM MDM2-A1 OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.

Human: MDM2, ISOFORM MDM2-B OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.

Human: MDM2, ISOFORM MDM2-ALPHA OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.

Human: MDM2, ISOFORM MDM2-C OF E3 UBIQUITIN-PROTEIN LIGASE MDM2.

Human: MDM2, MOUSE DOUBLE MINUTE 2 HOMOLOG ISOFORM MDM2E.

Human: MDM2, HDM2-HD5 PROTEIN.

Human: MDM2, HDM2-HD2 PROTEIN.

Human: MDM2, P53 BINDING PROTEIN.

Human: MDM2, P53-BINDING PROTEIN.

Human: MDM2, MDM2 VARIANT FB30.

Human: MDM2, MDM2 VARIANT FB29.

Human: MDM2, MOUSE DOUBLE MINUTE 2 HOMOLOG ISOFORM MDM2B.

Human: MDM2, MDM2 PROTEIN.

Human: MDM2, MOUSE DOUBLE MINUTE 2 HOMOLOG ISOFORM MDM2A.

Human: MDM2, P53 BINDING PROTEIN.

Human: MDM2, MOUSE DOUBLE MINUTE 2 HOMOLOG ISOFORM MDM2.

Human: MDM2, MDM2 VARIANT FB25.

Human: MDM2, MDM2 VARIANT FB55.

Human: MDM2, 9 KDA PROTEIN.

Human: MDM2, 26 KDA PROTEIN.

Human: MDM2, UNCHARACTERIZED PROTEIN MDM2.

Annotations for MDM2 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
nucleolus	C		IDA	ISS ISS
cytoplasm	C		IDA	ISS
nucleus	C	IEA	IDA IDA IDA IDA	ISS IEA
intracellular	C	IEA	IEA	IEA
nucleoplasm	C			ISS
metal ion binding	F	IEA	IEA
enzyme binding	F			ISS
p53 binding	F		IPI
ligase activity	F		IEA
ubiquitin-protein ligase activity	F		IDA	ISS ISS
zinc ion binding	F	IEA	IEA IEA	ISS IEA
protein binding	F	IEA	IPI	ISS IEA
negative regulator of basal transcription activity	F			ISS
traversing start control point of mitotic cell cycle	P		IDA	ISS
protein complex assembly	P			ISS
regulation of protein catabolic process	P			ISS
regulation of progression through cell cycle	P			ISS
negative regulation of cell proliferation	P			ISS
protein catabolic process	P		IDA	ISS
ubiquitin cycle	P		IEA
protein ubiquitination	P		IDA	ISS ISS
negative regulation of transcription from RNA polymerase II promoter	P			ISS

Cellular Component

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Phenotype (14)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Mouse
cellular phenotype	MP	Un Un Un
embryogenesis phenotype	MP	Un Un Un
immune system phenotype	MP	Un Un
lethality-embryonic/perinatal	MP	Un Un Un Un
muscle phenotype	MP	Un Un
lethality-postnatal	MP	Un
renal/urinary system phenotype	MP	Un Un
cardiovascular system phenotype	MP	Un Un
digestive/alimentary phenotype	MP	Un Un
normal phenotype	MP	Un Un Un Un
hematopoietic system phenotype	MP	Un Un
no phenotypic analysis	MP	Un Un
growth/size phenotype	MP	Un Un Un Un
liver/biliary system phenotype	MP	Un Un

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Glioma (05214)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Chronic myeloid leukemia (05220)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Cell cycle (04110)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway