IpiRecord: IPI00216232

IPI00216232 - NOS1, ISOFORM 4 OF NITRIC-OXIDE SYNTHASE, BRAIN.
Uniprot Accession: P29475-4
Uniprot ID: NOS1_HUMAN
Mapping: Chr 12, 116135362 - 116283965
Entrez Gene: 4842
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_11082)
Rat: Nos1, ISOFORM N-NOS-1 OF NITRIC-OXIDE SYNTHASE, BRAIN.
Mouse: Nos1, ISOFORM N-NOS-1 OF NITRIC-OXIDE SYNTHASE, BRAIN.
Mouse: Nos1, ISOFORM N-NOS-2 OF NITRIC-OXIDE SYNTHASE, BRAIN.
Mouse: Nos1, ISOFORM NNOS BETA OF NITRIC-OXIDE SYNTHASE, BRAIN.
Mouse: Nos1, ISOFORM NNOS MU OF NITRIC-OXIDE SYNTHASE, BRAIN.
Mouse: Nos1, ISOFORM NNOS GAMMA OF NITRIC-OXIDE SYNTHASE, BRAIN.
Rat: Nos1, ISOFORM N-NOS-2 OF NITRIC-OXIDE SYNTHASE, BRAIN.
Rat: Nos1, ISOFORM PNNOS OF NITRIC-OXIDE SYNTHASE, BRAIN.
Rat: Nos1, 41 KDA PROTEIN.
Human: NOS1, ISOFORM 4 OF NITRIC-OXIDE SYNTHASE, BRAIN.
Human: NOS1, ISOFORM 1 OF NITRIC-OXIDE SYNTHASE, BRAIN.
Human: NOS1, ISOFORM 3 OF NITRIC-OXIDE SYNTHASE, BRAIN.
Human: NOS1, ISOFORM 2 OF NITRIC-OXIDE SYNTHASE, BRAIN.
Human: NOS1, 4 KDA PROTEIN.
Human: NOS1, NEURONAL NITRIC-OXIDE SYNTHASE ISOFORM MU.
Human: NOS1, 2 KDA PROTEIN.

Annotations for NOS1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmCIDA IDA 
plasma membraneCIDA 
cytosolCIDA 
membraneCIEA 
dendriteCIDA 
mitochondrial outer membraneCIDA 
cell projectionCIEA 
synapseCIDA IDA ISS 
nuclear membraneCIDA 
mitochondrionCISS IDA 
nucleusCIDA 
membrane fractionCISS 
sarcolemmaCIDA 
azurophil granuleCIDA 
FAD bindingFIEA TAS IDA 
metal ion bindingFIEA 
NADP bindingFIEA TAS IDA 
FMN bindingFIEA TAS IDA 
iron ion bindingFIEA IEA 
oxidoreductase activityFIEA IEA IEA 
electron carrier activityFIEA 
nitric-oxide synthase activityFIEA IEA IEA TAS ISS IDA IDA 
protein bindingFISS IPI 
amino acid bindingFTAS 
heme bindingFIEA TAS 
enzyme bindingFIPI 
calmodulin bindingFIEA IEA IDA 
nitric oxide biosynthetic processPIEA IDA 
striated muscle contractionPIMP ISS 
cell-cell signalingPISS 
regulation of sodium ion transportPIMP 
exogenous drug catabolic processPIMP 
synaptic transmissionPISS 
negative regulation of calcium ion transportPIMP 
negative regulation of hydrolase activityPIMP 
negative regulation of blood pressurePIMP 
negative regulation of heart contractionPIMP 
negative regulation of potassium ion transportPIMP 
regulation of heart contractionPIMP 
electron transportPIEA IDA 
muscle contractionPISS 
response to ethanolPIEP 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (10)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
behavior/neurological phenotypeMPUn
endocrine/exocrine gland phenotypeMPUn
homeostasis/metabolism phenotypeMPUn Un
nervous system phenotypeMPUn Un Un
vision/eye phenotypeMPUn
cardiovascular system phenotypeMPUn
digestive/alimentary phenotypeMPUn Un
reproductive system phenotypeMPUn Un
growth/size phenotypeMPUn
life span-post-weaning/agingMPUn

Disease (20)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Kidney Failure, ChronicDIEP
ObesityDIEP
SepsisDIPM
Memory DisordersDIPM
Fetal AnoxiaDIEP
CardiomegalyDIEP
Diabetes Mellitus, Non-Insulin-DependentDIEP
Nephrotic SyndromeDIEP
Diabetes Mellitus, ExperimentalDIEP
Myocardial DiseasesDIEP
ArteriosclerosisDISS
Hypertension, RenovascularDIEP
Cardiomyopathy, AlcoholicDIEP
Brain IschemiaDIPM
Diabetic RetinopathyDIEP
Hepatic EncephalopathyDIEP
Heat StrokeDIEP
Reperfusion InjuryDIPM
Heart Failure, CongestiveDIEP
HypertensionDIEPIEPIEPIEP

Pathway (2)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
Parkinson disease pathwayWISS
arginine and proline metabolic pathwayWIEA

KEGG Pathway (3)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Long-term depression (04730)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Calcium signaling pathway (04020)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Arginine and proline metabolism (00330)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway