IPI report for IPI00218661

IpiRecord: IPI00218661

IPI00218661 - ITPR1, ISOFORM 5 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Uniprot Accession: Q14643-5
Uniprot ID: ITPR1_HUMAN
Mapping: Chr 3, 4510136 - 4863432
Entrez Gene: 3708
Entrez MapView:
+All IPI Database Cross References UniProtKB/Swiss-Prot: Q14643-5 UniProtKB/Swiss-Prot: ITPR1_HUMAN UniParc: UPI000002ABEF HGNC: 6180 Entrez Gene: 3708 UniGene: Hs.567295 UniGene: Hs.699169 UTRdb: BB052782 RZPD: Hs.567295 InterPro: IPR000699 InterPro: IPR014821 InterPro: IPR000493 InterPro: IPR005821 InterPro: IPR003608 InterPro: IPR013662 InterPro: IPR015925 Pfam: PF08709 Pfam: PF00520 Pfam: PF02815 Pfam: PF08454 Pfam: PF01365 PRINTS: PR00779 SMART: SM00472 PROSITE: PS50919 PANTHER: PTHR13715

IPI00218661 - ITPR1, ISOFORM 5 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Uniprot Accession: Q14643-5

Uniprot ID: ITPR1_HUMAN

Mapping: Chr 3, 4510136 - 4863432

Entrez Gene: 3708

Entrez MapView: Geneprod

+All IPI Database Cross References

IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4847)
Rat: Itpr1, ISOFORM 1 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Mouse: Itpr1, ISOFORM 7 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Mouse: Itpr1, ISOFORM 3 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Mouse: Itpr1, ISOFORM 4 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Mouse: Itpr1, ISOFORM 5 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Mouse: Itpr1, ISOFORM 6 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Mouse: Itpr1, ISOFORM 8 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Mouse: Itpr1, ISOFORM 1 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Mouse: Itpr1, ISOFORM 2 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Rat: Itpr1, ISOFORM 2 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Rat: Itpr1, ISOFORM 3 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Rat: Itpr1, ISOFORM 4 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Rat: Itpr1, ISOFORM 5 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Rat: Itpr1, ISOFORM 6 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Rat: Itpr1, ISOFORM 7 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Rat: Itpr1, ISOFORM 8 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Human: ITPR1, ISOFORM 2 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Human: ITPR1, ISOFORM 3 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Human: ITPR1, ISOFORM 4 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Human: ITPR1, ISOFORM 5 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Human: ITPR1, ISOFORM 6 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Human: ITPR1, ISOFORM 7 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Human: ITPR1, ISOFORM 8 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Human: ITPR1, ISOFORM 1 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.
Human: ITPR1, 20 KDA PROTEIN.
Human: ITPR1, 10 KDA PROTEIN.

IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4847)

Rat: Itpr1, ISOFORM 1 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Mouse: Itpr1, ISOFORM 7 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Mouse: Itpr1, ISOFORM 3 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Mouse: Itpr1, ISOFORM 4 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Mouse: Itpr1, ISOFORM 5 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Mouse: Itpr1, ISOFORM 6 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Mouse: Itpr1, ISOFORM 8 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Mouse: Itpr1, ISOFORM 1 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Mouse: Itpr1, ISOFORM 2 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Rat: Itpr1, ISOFORM 2 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Rat: Itpr1, ISOFORM 3 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Rat: Itpr1, ISOFORM 4 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Rat: Itpr1, ISOFORM 5 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Rat: Itpr1, ISOFORM 6 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Rat: Itpr1, ISOFORM 7 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Rat: Itpr1, ISOFORM 8 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Human: ITPR1, ISOFORM 2 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Human: ITPR1, ISOFORM 3 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Human: ITPR1, ISOFORM 4 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Human: ITPR1, ISOFORM 5 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Human: ITPR1, ISOFORM 6 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Human: ITPR1, ISOFORM 7 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Human: ITPR1, ISOFORM 8 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Human: ITPR1, ISOFORM 1 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1.

Human: ITPR1, 20 KDA PROTEIN.

Human: ITPR1, 10 KDA PROTEIN.

Annotations for ITPR1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Mouse	Rat
plasma membrane	C		IDA
integral to plasma membrane	C		ISS
integral to membrane	C	IEA
postsynaptic density	C		IDA
protein complex	C	IPI
lipid raft	C		IDA
membrane	C	IEA IEA
endoplasmic reticulum membrane	C		ISS IDA
secretory granule membrane	C		IDA
endoplasmic reticulum	C	TAS	ISS ISS
inositol 1,4,5-triphosphate-sensitive calcium-release channel activity	F	IEA
calcium channel activity	F	IEA IEA
calcium ion transmembrane transporter activity	F		ISS
calcium ion binding	F	IEA
receptor activity	F	IEA
protein binding	F	IPI	ISS ISS IPI IDA
ion channel activity	F	IEA IEA
inositol-1,4,5-triphosphate receptor activity	F	TAS	ISS ISS
calcium ion transport	P	IEA IEA	ISS
transport	P	IEA
elevation of cytosolic calcium ion concentration	P		IMP
ion transport	P	IEA IEA
signal transduction	P		ISS

Cellular Component

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Phenotype (8)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Mouse
cellular phenotype	MP	Un
behavior/neurological phenotype	MP	Un Un Un
lethality-embryonic/perinatal	MP	Un
lethality-postnatal	MP	Un Un
muscle phenotype	MP	Un
nervous system phenotype	MP	Un Un
growth/size phenotype	MP	Un
life span-post-weaning/aging	MP	Un Un

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
Cardiomyopathy, Congestive	D			ISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
GnRH signaling pathway (04912)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Long-term depression (04730)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Calcium signaling pathway (04020)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Gap junction (04540)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Long-term potentiation (04720)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Phosphatidylinositol signaling system (04070)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway