IpiRecord: IPI00218845

IPI00218845 - NOS3, NITRIC-OXIDE SYNTHASE, ENDOTHELIAL.
Uniprot Accession: Q9UDC6
Uniprot ID: Q9UDC6_HUMAN
Mapping: Chr 7, 150319080 - 150342608
Entrez Gene: 4846
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4274)
Rat: Nos3, NITRIC-OXIDE SYNTHASE, ENDOTHELIAL.
Mouse: Nos3, NITRIC OXIDE SYNTHASE 3, ENDOTHELIAL CELL.
Mouse: Nos3, NITRIC-OXIDE SYNTHASE, ENDOTHELIAL.
Mouse: Nos3, ENDOTHELIAL NITRIC OXIDE SYNTHASE.
Human: NOS3, NITRIC-OXIDE SYNTHASE, ENDOTHELIAL.
Human: NOS3, 9 KDA PROTEIN.

Annotations for NOS3 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
Golgi apparatusCIEA IEA 
cytoplasmCTAS IEA ISS 
apical part of cellCIDA 
cytoskeletonCIEA IEA 
soluble fractionCIDA 
membraneCIEA IEA 
FAD bindingFIEA 
nitric-oxide synthase activityFTAS IMP IMP ISS ISS IDA IEA 
electron carrier activityFIEA 
protein bindingFIPI IDA 
metal ion bindingFIEA 
calcium ion bindingFIEA IEA IEA 
iron ion bindingFIEA IEA IEA 
NADP bindingFIEA 
heme bindingFIEA 
FMN bindingFIEA IEA IEA 
calmodulin bindingFIEA IEA IEA 
zinc ion bindingFIEA IEA IEA 
oxidoreductase activityFIEA IEA IEA IEA 
nitric oxide biosynthetic processPIEA IMP ISS IMP IEA 
lung developmentPIEA IMP 
lipopolysaccharide-mediated signaling pathwayPIEA IMP ISS IEA 
cell motilityPTAS ISS 
regulation of sodium ion transportPIEA IMP IEA 
negative regulation of hydrolase activityPIEA IMP IEA 
angiogenesisPIEA IMP 
amino acid metabolic processPNR ISS 
negative regulation of potassium ion transportPIEA IMP IEA 
learningPIEA IMP ISS IEA 
ovulation from ovarian folliclePIEA IMP ISS IEA 
electron transportPIEA IEA IEA 
negative regulation of calcium ion transportPIEA IMP IEA 
negative regulation of smooth muscle cell proliferationPIMP IMP 
signal transductionPIMP 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (15)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn
endocrine/exocrine gland phenotypeMPUn
behavior/neurological phenotypeMPUn
homeostasis/metabolism phenotypeMPUn Un Un
immune system phenotypeMPUn
lethality-embryonic/perinatalMPUn
muscle phenotypeMPUn
lethality-postnatalMPUn Un
nervous system phenotypeMPUn
respiratory system phenotypeMPUn
limbs/digits/tail phenotypeMPUn
cardiovascular system phenotypeMPUn Un Un
reproductive system phenotypeMPUn Un
growth/size phenotypeMPUn
life span-post-weaning/agingMPUn

Disease (4)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Myocardial InfarctionDISSISS
Hypertension, PortalDIED
Coronary VasospasmDISS
HypertensionDIEDISSISSISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (4)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Long-term depression (04730)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
VEGF signaling pathway (04370)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Calcium signaling pathway (04020)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Arginine and proline metabolism (00330)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway