IpiRecord: IPI00219307

IPI00219307 - CASP1, ISOFORM BETA OF CASPASE-1 PRECURSOR.
Uniprot Accession: P29466-2
Uniprot ID: CASP1_HUMAN
Mapping: Chr 11, 104401458 - 104477368
Entrez Gene: 834
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7623)
Rat: Casp1, CASPASE-1 PRECURSOR.
Mouse: Casp1, CASPASE-1 PRECURSOR.
Human: CASP1, ISOFORM ALPHA OF CASPASE-1 PRECURSOR.
Human: CASP1, ISOFORM BETA OF CASPASE-1 PRECURSOR.
Human: CASP1, ISOFORM GAMMA OF CASPASE-1 PRECURSOR.
Human: CASP1, ISOFORM DELTA OF CASPASE-1 PRECURSOR.
Human: CASP1, ISOFORM EPSILON OF CASPASE-1 PRECURSOR.
Human: INCA, INCA.
Human: CASP1, CASP1 NIRS VARIANT 1.
Human: CASP1, 43 KDA PROTEIN.
Human: CASP1, ISOFORM ZETA OF CASPASE-1 PRECURSOR.

Annotations for CASP1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
intracellularCIEA IEA IEA 
cytoplasmCTAS ISS 
extracellular regionCIDA ISS IEA 
caspase activator activityFISS 
peptidase activityFIEA 
hydrolase activityFIEA 
signal transducer activityFISS 
protein bindingFIEA IPI IPI ISS ISS IEA 
cysteine-type peptidase activityFIEA IEA IEA 
caspase activityFIEA IEA ISS ISS IEA 
catalytic activityFIEA 
metabolic processPIEA 
apoptosisPIEA IEP 
response to hypoxiaPIMP ISS IEA 
induction of apoptosisPIDA IMP IEA ISS IEA 
cell deathPIDA ISS IEA 
regulation of apoptosisPIEA IEA IEA 
positive regulation of I-kappaB kinase/NF-kappaB cascadePISS 
protein processingPIDA IMP ISS IEA 
signal transductionPISS 
proteolysisPIEA IEA ISS IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (8)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn Un
homeostasis/metabolism phenotypeMPUn
immune system phenotypeMPUn Un
renal/urinary system phenotypeMPUn
nervous system phenotypeMPUn
tumorigenesisMPUn
hematopoietic system phenotypeMPUn
reproductive system phenotypeMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (3)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
programmed cell death pathwayWIEA
mitogen activated protein kinase signaling pathwayWIEA
Huntington disease pathwayWIEA

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Huntington's disease (05040)Present in KEGG pathway Not present in KEGG pathwayPresent in KEGG pathway
Dentatorubropallidoluysian atrophy (DRPLA) (05050)Present in KEGG pathway Not present in KEGG pathwayPresent in KEGG pathway
Neurodegenerative Disorders (01510)Present in KEGG pathway Not present in KEGG pathwayPresent in KEGG pathway