IpiRecord: IPI00221301

IPI00221301 - CTH, ISOFORM 2 OF CYSTATHIONINE GAMMA-LYASE.
Uniprot Accession: P32929-2
Uniprot ID: CGL_HUMAN
Mapping: Chr 1, 70649543 - 70677841
Entrez Gene: 1491
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_2942)
Rat: Cth, CYSTATHIONINE GAMMA-LYASE.
Mouse: Cth, CYSTATHIONINE GAMMA-LYASE.
Human: CTH, ISOFORM 1 OF CYSTATHIONINE GAMMA-LYASE.
Human: CTH, ISOFORM 2 OF CYSTATHIONINE GAMMA-LYASE.

Annotations for CTH and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cellular_componentCND ND 
cytoplasmCIEA 
catalytic activityFIEA 
lyase activityFIEA IEA 
cystathionine gamma-lyase activityFIDA ISS ISS IEA 
cystathionine beta-lyase activityFIDA 
pyridoxal phosphate bindingFIEA TAS IEA 
negative regulation of cell proliferationPIMP 
glutathione metabolic processPIMP 
cysteine biosynthetic processPIEA IDA IEA 
amino acid biosynthetic processPIEA IEA 
amino acid metabolic processPIEA 
negative regulation of cell growthPIMP 
homocysteine metabolic processPIDA 
transsulfurationPTAS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (0)

There are no Mammalian Phenotype Ontology annotations for this protein in the database

Disease (2)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Amino Acid Metabolism, Inborn ErrorsDISS
CataractDIED

Pathway (6)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
methionine cycle/metabolic pathwayWIEA
cysteine metabolic pathwayWIEA IDA
nitrogen metabolic pathwayWIEA
selenoamino acid metabolic pathwayWIEA
glycine, serine and threonine metabolic pathwayWIEA
transulfuration pathway of homocysteine metabolismWIDA

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Glycine, serine and threonine metabolism (00260)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Methionine metabolism (00271)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Selenoamino acid metabolism (00450)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cysteine metabolism (00272)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Nitrogen metabolism (00910)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway