IpiRecord: IPI00235354

IPI00235354 - TGFB2, ISOFORM A OF TRANSFORMING GROWTH FACTOR BETA-2 PRECURSOR.
Uniprot Accession: P61812-1
Uniprot ID: TGFB2_HUMAN
Mapping: Chr 1, 216586200 - 216684584
Entrez Gene: 7042
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_11615)
Rat: Tgfb2, ISOFORM TGF-BETA2B OF TRANSFORMING GROWTH FACTOR BETA-2 PRECURSOR.
Mouse: Tgfb2, TRANSFORMING GROWTH FACTOR BETA-2 PRECURSOR.
Mouse: Tgfb2, TRANSFORMING GROWTH FACTOR BETA 2 (FRAGMENT).
Rat: Tgfb2, ISOFORM TGF-BETA2A OF TRANSFORMING GROWTH FACTOR BETA-2 PRECURSOR.
Rat: Tgfb2, 10 KDA PROTEIN.
Rat: Tgfb2, TGFB2 PROTEIN.
Human: TGFB2, ISOFORM B OF TRANSFORMING GROWTH FACTOR BETA-2 PRECURSOR.
Human: TGFB2, ISOFORM A OF TRANSFORMING GROWTH FACTOR BETA-2 PRECURSOR.

Annotations for TGFB2 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
secretory granuleCIDA 
axonCIDA 
extracellular spaceCRCA IDA ISS 
trans-Golgi networkCIDA 
cell surfaceCIDA 
cell somaCIDA 
growth factor activityFTAS IEA 
protein bindingFIPI ISS 
transforming growth factor beta receptor bindingFIEA TAS IEA 
beta-amyloid bindingFISS 
protein N-terminus bindingFIMP 
hair follicle morphogenesisPIMP 
negative regulation of apoptosisPIDA 
regulation of apoptosisPIMP ISS 
positive regulation of progression through cell cyclePIMP 
neuron developmentPIMP 
hair follicle developmentPIMP ISS 
blood vessel developmentPIMP ISS 
somatic stem cell divisionPIDA 
negative regulation of immune responsePIDA 
heart developmentPIMP ISS ISS 
regulation of progression through cell cyclePIEA 
positive regulation of neuron apoptosisPISS 
negative regulation of release of sequestered calcium ion into cytosolPIDA 
positive regulation of cell proliferationPIDA 
negative regulation of cell proliferationPIMP 
neuron fate commitmentPIDA ISS 
axon guidancePIMP ISS 
epithelial to mesenchymal transitionPISS 
cell proliferationPIEA 
hemopoiesisPIMP 
dopamine biosynthetic processPIMP 
endothelial cell activationPISS 
lung developmentPTAS 
extracellular matrix organization and biogenesisPIMP IMP ISS 
regulation of cell proliferationPTAS 
regulation of cell growthPTAS 
response to estrogen stimulusPIDA 
negative regulation of keratinocyte differentiationPNAS 
cell growthPIEA IEA 
blood vessel remodelingPIMP ISS 
skeletal developmentPIMP ISS 
embryonic neurocranium morphogenesisPIDA 
positive regulation of cell migrationPIDA 
growthPIEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (17)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
craniofacial phenotypeMPUn
endocrine/exocrine gland phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
immune system phenotypeMPUn
lethality-embryonic/perinatalMPUn
skeleton phenotypeMPUn
muscle phenotypeMPUn
renal/urinary system phenotypeMPUn
nervous system phenotypeMPUn
respiratory system phenotypeMPUn
vision/eye phenotypeMPUn
cardiovascular system phenotypeMPUn
digestive/alimentary phenotypeMPUn
limbs/digits/tail phenotypeMPUn
reproductive system phenotypeMPUn
hearing/vestibular/ear phenotypeMPUn
growth/size phenotypeMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Chronic myeloid leukemia (05220)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
TGF-beta signaling pathway (04350)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cell cycle (04110)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
MAPK signaling pathway (04010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Colorectal cancer (05210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cytokine-cytokine receptor interaction (04060)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Pancreatic cancer (05212)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway