IpiRecord: IPI00247063

IPI00247063 - MME, NEPRILYSIN.
Uniprot Accession: P08473
Uniprot ID: NEP_HUMAN
Mapping: Chr 3, 156284651 - 156384186
Entrez Gene: 4311
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_2432)
Rat: Mme, NEPRILYSIN.
Mouse: Mme, NEPRILYSIN.
Human: MME, NEPRILYSIN.
Human: MME, MME PROTEIN.
Human: MME, 9 KDA PROTEIN.
Human: MME, 4 KDA PROTEIN.

Annotations for MME and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
integral to plasma membraneCTAS ISS 
plasma membraneCTAS IMP ISS 
membrane fractionCIDA 
membraneCIEA IDA ISS IEA 
integral to membraneCRCA ISS IEA 
metallopeptidase activityFTAS IEA IEA ISS IEA 
zinc ion bindingFIEA IEA IEA IEA 
protein bindingFIPI 
peptide bindingFIMP IDA 
neprilysin activityFIEA IDA IMP ISS IEA IDA 
metal ion bindingFIEA IEA IEA 
peptidase activityFIEA 
hydrolase activityFIEA 
peptide metabolic processPIMP 
proteolysisPTAS IEA IEA IMP ISS IDA IEA 
cell-cell signalingPTAS ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (4)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
skin/coat/nails phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
immune system phenotypeMPUn
liver/biliary system phenotypeMPUn

Disease (3)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Glomerulonephritis, MembranousDISS
Cerebral Amyloid AngiopathyDISS
Alzheimer DiseaseDISS

Pathway (2)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
renin-angiotensin system signaling pathwayWISSISSIMP
angiotensin (1-7) signaling pathwayWISSISSIMP

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Alzheimer's disease (05010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Hematopoietic cell lineage (04640)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway