IpiRecord: IPI00290116

IPI00290116 - CYP11B2, CYTOCHROME P450 11B2, MITOCHONDRIAL PRECURSOR.
Uniprot Accession: Q16315
Uniprot ID: Q16315_HUMAN
Mapping: Chr 8, 143988983 - 143996261
Entrez Gene: 1585
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7244)
Rat: Cyp11b2, CYTOCHROME P450 11B2, MITOCHONDRIAL PRECURSOR.
Mouse: Cyp11b2, CYTOCHROME P450 11B2, MITOCHONDRIAL PRECURSOR.
Mouse: Cyp11b2, CYTOCHROME P450, FAMILY 11, SUBFAMILY B, POLYPEPTIDE 2.
Human: CYP11B2, CYTOCHROME P450 11B2, MITOCHONDRIAL PRECURSOR.
Human: CYP11B2, STEROID 18-HYDROXYLASE (FRAGMENT).

Annotations for CYP11B2 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
dendriteCIDA 
membraneCIEA IEA IEA 
mitochondrionCIEA IEA IEA IEA 
oxidoreductase activityFIEA 
oxygen bindingFNR ISS 
monooxygenase activityFIEA IEA IEA IEA 
iron ion bindingFIEA IEA IEA IEA 
corticosterone 18-monooxygenase activityFIEA IEA IDA IEA IDA 
metal ion bindingFIEA IEA IEA 
steroid 11-beta-monooxygenase activityFTAS IDA IDA IDA ISS IEA 
heme bindingFIEA IEA IEA 
electron transportPIEA IEA IEA 
regulation of blood pressure by circulatory renin-angiotensinPIMP ISS IEA 
drinking behaviorPIMP ISS IEA 
lipid metabolic processPIEA 
aldosterone mediated regulation of body fluidsPIMP ISS IEA 
steroid metabolic processPIEA 
C21-steroid hormone biosynthetic processPIEA IEA IDA IEA 
ion homeostasisPIMP ISS IEA 
aldosterone biosynthetic processPIDA IDA 
blood pressure regulationPTAS ISS 
glucocorticoid biosynthetic processPTAS ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (11)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
growth/size phenotypeMPUn
endocrine/exocrine gland phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
cardiovascular system phenotypeMPUn
lethality-postnatalMPUn
decreased urine outputNIAGP
increased circulating corticosterone levelNIAGP
abnormal adrenal gland morphologyNIAGP
increased circulating aldosterone levelNIAGP
small thymusNIAGP
decreased left ventricle weightNIAGP

Disease (6)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Cardiomyopathy, HypertrophicDISS
Hypertrophy, Left VentricularDISS
HyperaldosteronismDISS
Pre-EclampsiaDISS
HypoaldosteronismDISS
HypertensionDISS

Pathway (2)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
C21-Steroid hormone metabolic pathwayWIEA IDA
androgen and estrogen metabolic pathwayWIEA

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
C21-Steroid hormone metabolism (00140)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Androgen and estrogen metabolism (00150)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway