IpiRecord: IPI00291005

IPI00291005 - MDH1, MALATE DEHYDROGENASE, CYTOPLASMIC.
Uniprot Accession: P40925
Uniprot ID: MDHC_HUMAN
Mapping: Chr 2, 63669626 - 63687832
Entrez Gene: 4190
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_12093)
Rat: Mdh1, MALATE DEHYDROGENASE, CYTOPLASMIC.
Mouse: Mdh1, MALATE DEHYDROGENASE, CYTOPLASMIC.
Mouse: Mdh1, MALATE DEHYDROGENASE, SOLUBLE.
Human: MDH1, MALATE DEHYDROGENASE, CYTOPLASMIC.

Annotations for MDH1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytosolCTAS ISS ISS 
cytoplasmCIEA IEA 
soluble fractionCIDA 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorFIEA 
malic enzyme activityFTAS ISS 
NAD bindingFIDA 
malate dehydrogenase activityFIEA IDA 
L-lactate dehydrogenase activityFIEA 
L-malate dehydrogenase activityFIEA IEA IEA IDA IEA 
oxidoreductase activityFIEA IEA IEA IEA 
tricarboxylic acid cycle intermediate metabolic processPIEA 
cellular carbohydrate metabolic processPIEA 
malate metabolic processPIEA IEA IDA IEA 
oxaloacetate metabolic processPIDA 
tricarboxylic acid cyclePIEA IEA IEA 
glycolysisPIEA IEA IEA 
NAD metabolic processPIDA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (2)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
homeostasis/metabolism phenotypeMPUn
lethality-embryonic/perinatalMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (5)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
citrate cycle pathwayWIEA
reductive carboxylate cycle - CO2 fixation pathwayWIEA
pyruvate metabolic pathwayWIEA
carbon fixation pathwayWIEA
glyoxylate and dicarboxylate metabolic pathwayWIEA

KEGG Pathway (5)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Citrate cycle (TCA cycle) (00020)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Carbon fixation (00710)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Glyoxylate and dicarboxylate metabolism (00630)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Reductive carboxylate cycle (CO2 fixation) (00720)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pyruvate metabolism (00620)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway