IpiRecord: IPI00292646

IPI00292646 - GAD1, ISOFORM 1 OF GLUTAMATE DECARBOXYLASE 1.
Uniprot Accession: Q8IVA8
Uniprot ID: Q8IVA8_HUMAN
Mapping: Chr 2, 171381318 - 171425907
Entrez Gene: 2571
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_3267)
Rat: Gad1, GLUTAMATE DECARBOXYLASE 1.
Mouse: Gad1, GLUTAMATE DECARBOXYLASE 1.
Mouse: Gad1, INSERT SEQUENCE.
Rat: Gad1, GLUTAMATE DECARBOXYLASE.
Human: GAD1, ISOFORM 1 OF GLUTAMATE DECARBOXYLASE 1.
Human: GAD1, GAD1 PROTEIN.
Human: GAD1, ISOFORM 3 OF GLUTAMATE DECARBOXYLASE 1.

Annotations for GAD1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmCIDA ISS 
synapseCIDA ISS 
vesicle membraneCISS 
mitochondrionCIDA ISS 
intracellularCISS ISS 
axonCIDA ISS 
pyridoxal phosphate bindingFIEA IEA IEA 
carboxy-lyase activityFIEA IEA IEA 
catalytic activityFIEA 
lyase activityFIEA IEA IEA 
protein bindingFISS ISS 
glutamate decarboxylase activityFIEA IEA IDA ISS ISS 
synaptic transmissionPIEA IEA ISS 
glutamate decarboxylation to succinatePISS 
protein-pyridoxal-5-phosphate linkagePISS 
neurotransmitter biosynthetic processPIEA IEA 
carboxylic acid metabolic processPIEA IEA IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (13)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
craniofacial phenotypeMPUn Un Un
growth/size phenotypeMPUn
behavior/neurological phenotypeMPUn Un
homeostasis/metabolism phenotypeMPUn
embryogenesis phenotypeMPUn
lethality-embryonic/perinatalMPUn Un Un
digestive/alimentary phenotypeMPUn Un
skeleton phenotypeMPUn
nervous system phenotypeMPUn Un
respiratory system phenotypeMPUn Un
life span-post-weaning/agingMPUn
perinatal lethalityNISS
cleft palateNISS

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (5)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
beta-alanine metabolic pathwayWIEA
alanine and aspartate metabolic pathwayWIEA
glutamate metabolic pathwayWIEA
taurine and hypotaurine metabolic pathwayWIEA
butanoate metabolic pathwayWIEA

KEGG Pathway (6)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
beta-Alanine metabolism (00410)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Taurine and hypotaurine metabolism (00430)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Glutamate metabolism (00251)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Type I diabetes mellitus (04940)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Butanoate metabolism (00650)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Alanine and aspartate metabolism (00252)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway