IpiRecord: IPI00293683

IPI00293683 - MAPT, ISOFORM TAU-A OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Uniprot Accession: P10636-3
Uniprot ID: TAU_HUMAN
Mapping: Chr 17, 41327624 - 41461547
Entrez Gene: 4137
Entrez MapView:
+All IPI Database Cross References UniProtKB/Swiss-Prot: P10636-3 UniProtKB/Swiss-Prot: TAU_HUMAN Vega: OTTHUMP00000181551 REFSEQ_REVIEWED: NP_058525 REFSEQ_REVIEWED: GI:8400715 ENSEMBL: ENSP00000334886 ENSEMBL: ENSG00000186868 H-InvDB: HIT000302402 UniParc: UPI0000000C16 HGNC: 6893 Entrez Gene: 4137 UniGene: Hs.101174 CCDS: CCDS11502.1 UTRdb: BB008874 UTRdb: BB150975 UTRdb: BB269848 UTRdb: BB399137 UTRdb: BB399398 RZPD: Hs.101174 InterPro: IPR015562 InterPro: IPR002955 InterPro: IPR001084 Pfam: PF00418 PRINTS: PR01261 PROSITE: PS00229 PANTHER: PTHR11501:SF4

IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_10100)
Rat: Mapt, ISOFORM TAU-E OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Mouse: Mapt, 76 KDA PROTEIN.
Mouse: Mapt, ISOFORM TAU-C OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Mouse: Mapt, ISOFORM TAU-D OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Mouse: Mapt, ISOFORM TAU-E OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Mouse: Mapt, ISOFORM TAU-A OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Mouse: Mapt, ISOFORM TAU-B OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Mouse: Mapt, MICROTUBULE-ASSOCIATED PROTEIN TAU.
Mouse: Mapt, MICROTUBULE-ASSOCIATED PROTEIN TAU.
Mouse: Mapt, MICROTUBULE-ASSOCIATED PROTEIN TAU.
Mouse: Mapt, MICROTUBULE-ASSOCIATED PROTEIN TAU.
Mouse: Mapt, MICROTUBULE-ASSOCIATED PROTEIN TAU.
Mouse: Mapt, CLONE:1810048O14 PRODUCT:HYPOTHETICAL PROTEIN, FULL INSERT SEQUENCE.
Rat: Mapt, ISOFORM TAU-A OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Rat: Mapt, ISOFORM TAU-D OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Rat: Mapt, ISOFORM TAU-H OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Rat: Mapt, MICROTUBULE-ASSOCIATED PROTEIN.
Rat: Mapt, ISOFORM TAU-B OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Rat: Mapt, ISOFORM TAU-C OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Rat: Mapt, ISOFORM TAU-F OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Rat: Mapt, 37 KDA PROTEIN.
Rat: Mapt, ISOFORM TAU-G OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Human: MAPT, ISOFORM TAU-F OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Human: MAPT, ISOFORM TAU-D OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Human: MAPT, CDNA FLJ31424 FIS, CLONE NT2NE2000392.
Human: MAPT, ISOFORM TAU-G OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Human: MAPT, ISOFORM FETAL-TAU OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Human: MAPT, ISOFORM TAU-B OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Human: MAPT, ISOFORM TAU-C OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Human: MAPT, ISOFORM TAU-E OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Human: MAPT, ISOFORM TAU-A OF MICROTUBULE-ASSOCIATED PROTEIN TAU.
Human: MAPT, ISOFORM PNS-TAU OF MICROTUBULE-ASSOCIATED PROTEIN TAU.

Annotations for MAPT and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Mouse	Rat
plasma membrane	C		ISS ISS
cytoplasm	C	IEA
membrane	C	IEA
growth cone	C		ISS
microtubule	C	IEA
tubulin complex	C		ISS
cytosol	C		ISS ISS
axon	C	IDA	ISS ISS IDA
neuron projection	C		IDA
microtubule associated complex	C	IEA	ISS ISS
cytoskeleton	C	IEA
lipoprotein binding	F		ISS
structural constituent of cytoskeleton	F		ISS
enzyme binding	F		ISS
protein binding	F	IPI	ISS
SH3 domain binding	F		ISS
microtubule binding	F		IDA ISS
cytoskeletal regulatory protein binding	F	IEA
microtubule cytoskeleton organization and biogenesis	P		ISS
apoptosis	P		IDA
positive regulation of axon extension	P		ISS
positive regulation of microtubule polymerization	P		ISS
neuron differentiation	P		NAS
negative regulation of microtubule depolymerization	P	IEA	ISS IEA
response to organic substance	P		IDA
generation of neurons	P		ISS
microtubule-based process	P	IEA	NAS
response to nutrient	P		IDA

Cellular Component

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Phenotype (11)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Mouse
skin/coat/nails phenotype	MP	Un
homeostasis/metabolism phenotype	MP	Un
behavior/neurological phenotype	MP	Un Un
other phenotype	MP	Un
muscle phenotype	MP	Un
nervous system phenotype	MP	Un Un Un Un Un
vision/eye phenotype	MP	Un
normal phenotype	MP	Un Un Un
growth/size phenotype	MP	Un
life span-post-weaning/aging	MP	Un
no phenotypic analysis	MP	Un

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
Brain Ischemia	D			IED

Pathway (3)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Rat
Parkinson disease pathway	W	IEA
Alzheimer disease pathway	W	IEA
mitogen activated protein kinase signaling pathway	W	IEA

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Alzheimer's disease (05010)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
MAPK signaling pathway (04010)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Neurodegenerative Disorders (01510)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway