IpiRecord: IPI00295788

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
plasma membrane	C			IDA
cytoplasm	C		IDA
cytosol	C		IDA
phosphoinositide 3-kinase complex	C		TAS	TAS ISS
membrane	C		IDA
intracellular	C		IEA
kinase activity	F		IEA
phosphoinositide 3-kinase regulator activity	F		IEA
protein binding	F		IPI IPI IPI IPI	ISS IDA
receptor binding	F			IPI
1-phosphatidylinositol-3-kinase activity	F		TAS	TAS ISS
protein C-terminus binding	F			IDA
insulin receptor substrate binding	F		IPI	IPI
negative regulation of proteolysis	P			IMP
intracellular signaling cascade	P		IEA
response to insulin stimulus	P			IDA
response to glucocorticoid stimulus	P			IDA
B cell differentiation	P		IMP	ISS
negative regulation of apoptosis	P		IGI IDA	ISS
glucose metabolic process	P			IMP
negative regulation of cell-matrix adhesion	P		IGI
positive regulation of myoblast differentiation	P			IMP
response to cAMP	P			IDA
negative regulation of osteoclast differentiation	P		IGI
protein amino acid phosphorylation	P		IDA	ISS
positive regulation of anti-apoptosis	P			IMP
insulin-like growth factor receptor signaling pathway	P			IMP
insulin receptor signaling pathway	P			IMP
response to estrogen stimulus	P			IPI
positive regulation of cell migration	P		IGI
aging	P			IEP
signal transduction	P		IEA

Cellular Component

Biological Process

Molecular Function

Phenotype (13)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
adipose tissue phenotype	MP		Un Un
growth/size phenotype	MP		Un
homeostasis/metabolism phenotype	MP		Un Un Un
immune system phenotype	MP		Un Un
lethality-postnatal	MP		Un
muscle phenotype	MP		Un Un
cardiovascular system phenotype	MP		Un Un
hematopoietic system phenotype	MP		Un
normal phenotype	MP		Un
liver/biliary system phenotype	MP		Un
decreased circulating glucose level	N			ISS
increased insulin sensitivity	N			ISS
decreased mast cell number	N			ISS

Disease (4)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
Obesity	D			IEP ISS
Alzheimer Disease	D			ISS
Insulin Resistance	D			IEDISSISS
Hypertension, Portal	D			IED

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
insulin signaling pathway	W			IDA

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Glioma (05214)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
T cell receptor signaling pathway (04660)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Chronic myeloid leukemia (05220)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
B cell receptor signaling pathway (04662)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
mTOR signaling pathway (04150)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Toll-like receptor signaling pathway (04620)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Fc epsilon RI signaling pathway (04664)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Apoptosis (04210)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Jak-STAT signaling pathway (04630)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
VEGF signaling pathway (04370)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Type II diabetes mellitus (04930)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Leukocyte transendothelial migration (04670)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Colorectal cancer (05210)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Regulation of actin cytoskeleton (04810)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Pancreatic cancer (05212)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Insulin signaling pathway (04910)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Natural killer cell mediated cytotoxicity (04650)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Focal adhesion (04510)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Phosphatidylinositol signaling system (04070)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway