IpiRecord: IPI00296869

IPI00296869 - F2R, PROTEINASE-ACTIVATED RECEPTOR 1 PRECURSOR.
Uniprot Accession: Q71UT7
Uniprot ID: Q71UT7_HUMAN
Mapping: Chr 5, 76047542 - 76067054
Entrez Gene: 2149
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_2075)
Rat: F2r, PROTEINASE-ACTIVATED RECEPTOR 1 PRECURSOR.
Mouse: F2r, PROTEINASE-ACTIVATED RECEPTOR 1 PRECURSOR.
Rat: F2r, COAGULATION FACTOR II RECEPTOR.
Human: F2R, PROTEINASE-ACTIVATED RECEPTOR 1 PRECURSOR.

Annotations for F2R and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
plasma membraneCTAS ISS IDA 
postsynaptic membraneCIDA 
integral to plasma membraneCTAS ISS 
extracellular spaceCRCA ISS 
membraneCIEA 
Golgi apparatusCTAS ISS 
integral to membraneCRCA ISS IEA 
neuromuscular junctionCIDA 
receptor activityFIEA IEA IEA 
receptor bindingFTAS ISS 
thrombin receptor activityFTAS IEA TAS ISS IEA 
purinergic nucleotide receptor activity, G-protein coupledFRCA ISS 
rhodopsin-like receptor activityFIEA IEA IEA 
G-protein coupled receptor activityFIEA IEA 
signal transducer activityFIEA 
STAT protein nuclear translocationPTAS ISS 
anatomical structure morphogenesisPTAS ISS 
cell motilityPTAS ISS 
regulation of progression through cell cyclePTAS ISS 
response to woundingPTAS ISS 
positive regulation of calcium ion transportPIMP 
elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)PIMP 
establishment of synaptic specificity at neuromuscular junctionPIDA 
apoptosisPTAS ISS 
negative regulation of neuron apoptosisPIMP 
positive regulation of vasoconstrictionPIDA 
positive regulation of smooth muscle contractionPIDA 
regulation of sensory perception of painPIDA 
tyrosine phosphorylation of STAT proteinPTAS ISS 
protein kinase C activationPIMP 
caspase activationPTAS ISS 
positive regulation of cell proliferationPIDA 
release of sequestered calcium ion into cytosolPIMP 
positive regulation of I-kappaB kinase/NF-kappaB cascadePIEP ISS IEA 
activation of MAPKK activityPIMP 
multicellular organismal developmentPTAS 
signal transductionPTAS IEA ISS IEA 
blood coagulationPTAS IEA IEA IEA TAS ISS IEA 
G-protein coupled receptor protein signaling pathwayPIEA IEA IEA IDA IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (9)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn
growth/size phenotypeMPUn
embryogenesis phenotypeMPUn
lethality-embryonic/perinatalMPUn Un
hematopoietic system phenotypeMPUn
tumorigenesisMPUn
cardiovascular system phenotypeMPUn Un
nervous system phenotypeMPUn
abnormal nociception after inflammationNIED

Disease (5)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Coronary RestenosisDISS
Pre-EclampsiaDISS
Brain IschemiaDIEP
ThrombosisDISS
HypertensionDIED

Pathway (2)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
G protein signaling pathwayWIMP
The extracellular signal-regulated RAF/MEK/ERK pathwayWIMP

KEGG Pathway (4)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Neuroactive ligand-receptor interaction (04080)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Calcium signaling pathway (04020)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Regulation of actin cytoskeleton (04810)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Complement and coagulation cascades (04610)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway