| IPI00296869 - F2R, PROTEINASE-ACTIVATED RECEPTOR 1 PRECURSOR. | |
|---|---|
| Uniprot Accession: Q71UT7 | |
| Uniprot ID: Q71UT7_HUMAN | |
| Mapping: Chr 5, 76047542 - 76067054 | |
| Entrez Gene: 2149 | |
| Entrez MapView: |
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| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_2075) |
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| Rat: F2r, PROTEINASE-ACTIVATED RECEPTOR 1 PRECURSOR. |
| Mouse: F2r, PROTEINASE-ACTIVATED RECEPTOR 1 PRECURSOR. |
| Rat: F2r, COAGULATION FACTOR II RECEPTOR. |
| Human: F2R, PROTEINASE-ACTIVATED RECEPTOR 1 PRECURSOR. |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| plasma membrane | C | TAS | ISS IDA | |
| postsynaptic membrane | C | IDA | ||
| integral to plasma membrane | C | TAS | ISS | |
| extracellular space | C | RCA | ISS | |
| membrane | C | IEA | ||
| Golgi apparatus | C | TAS | ISS | |
| integral to membrane | C | RCA | ISS IEA | |
| neuromuscular junction | C | IDA | ||
| receptor activity | F | IEA | IEA | IEA |
| receptor binding | F | TAS | ISS | |
| thrombin receptor activity | F | TAS | IEA | TAS ISS IEA |
| purinergic nucleotide receptor activity, G-protein coupled | F | RCA | ISS | |
| rhodopsin-like receptor activity | F | IEA | IEA | IEA |
| G-protein coupled receptor activity | F | IEA IEA | ||
| signal transducer activity | F | IEA | ||
| STAT protein nuclear translocation | P | TAS | ISS | |
| anatomical structure morphogenesis | P | TAS | ISS | |
| cell motility | P | TAS | ISS | |
| regulation of progression through cell cycle | P | TAS | ISS | |
| response to wounding | P | TAS | ISS | |
| positive regulation of calcium ion transport | P | IMP | ||
| elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating) | P | IMP | ||
| establishment of synaptic specificity at neuromuscular junction | P | IDA | ||
| apoptosis | P | TAS | ISS | |
| negative regulation of neuron apoptosis | P | IMP | ||
| positive regulation of vasoconstriction | P | IDA | ||
| positive regulation of smooth muscle contraction | P | IDA | ||
| regulation of sensory perception of pain | P | IDA | ||
| tyrosine phosphorylation of STAT protein | P | TAS | ISS | |
| protein kinase C activation | P | IMP | ||
| caspase activation | P | TAS | ISS | |
| positive regulation of cell proliferation | P | IDA | ||
| release of sequestered calcium ion into cytosol | P | IMP | ||
| positive regulation of I-kappaB kinase/NF-kappaB cascade | P | IEP | ISS IEA | |
| activation of MAPKK activity | P | IMP | ||
| multicellular organismal development | P | TAS | ||
| signal transduction | P | TAS | IEA | ISS IEA |
| blood coagulation | P | TAS | IEA IEA IEA | TAS ISS IEA |
| G-protein coupled receptor protein signaling pathway | P | IEA | IEA IEA | IDA IEA |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| cellular phenotype | MP | Un | ||
| growth/size phenotype | MP | Un | ||
| embryogenesis phenotype | MP | Un | ||
| lethality-embryonic/perinatal | MP | Un Un | ||
| hematopoietic system phenotype | MP | Un | ||
| tumorigenesis | MP | Un | ||
| cardiovascular system phenotype | MP | Un Un | ||
| nervous system phenotype | MP | Un | ||
| abnormal nociception after inflammation | N | IED |
| DO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Coronary Restenosis | D | ISS | ||
| Pre-Eclampsia | D | ISS | ||
| Brain Ischemia | D | IEP | ||
| Thrombosis | D | ISS | ||
| Hypertension | D | IED |
| PW Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| G protein signaling pathway | W | IMP | ||
| The extracellular signal-regulated RAF/MEK/ERK pathway | W | IMP |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| Neuroactive ligand-receptor interaction (04080) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Calcium signaling pathway (04020) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Regulation of actin cytoskeleton (04810) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Complement and coagulation cascades (04610) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |