IpiRecord: IPI00302383

IPI00302383 - CFTR, CASSETTE SUB-FAMILY C MEMBER 7.
Uniprot Accession: Q20BJ8
Uniprot ID: Q20BJ8_HUMAN
Mapping: Chr 7, 116907253 - 117095951
Entrez Gene: 1080
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4360)
Rat: Cftr, CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR.
Mouse: Cftr, ISOFORM 1 OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR.
Mouse: Cftr, ISOFORM 2 OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR.
Mouse: Cftr, ISOFORM 3 OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR.
Mouse: Cftr, CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (FRAGMENT).
Mouse: Cftr, CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR.
Mouse: Cftr, REGULATOR HOMOLOG, FULL INSERT SEQUENCE.
Rat: Cftr, HOMOLOG.
Human: CFTR, CASSETTE SUB-FAMILY C MEMBER 7.
Human: CFTR, ISOFORM 1 OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR.
Human: CFTR, ISOFORM 3 OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR.
Human: CFTR, ISOFORM 2 OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR.
Human: CFTR, CASSETTE SUBFAMILY C MEMBER 7.

Annotations for CFTR and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmic vesicle membraneCIDA 
integral to membraneCIEA IEA RCA ISS IEA 
membraneCIEA IEA IEA IEA 
apical plasma membraneCIDA ISS 
basolateral plasma membraneCISS 
chloride channel activityFIEA IEA IEA IEA 
ATP-binding and phosphorylation-dependent chloride channel activityFISS 
ATPase activity, coupled to transmembrane movement of substancesFIEA IEA IEA 
ATP bindingFIEA IEA IEA ISS IEA 
nucleotide bindingFIEA IEA IEA IEA 
channel-conductance-controlling ATPase activityFISS 
nucleoside-triphosphatase activityFIEA 
chloride ion bindingFIEA 
PDZ domain bindingFISS 
protein bindingFISS 
molecular_functionFND 
ion channel activityFIEA 
ATPase activityFIEA IEA IEA 
lung developmentPIMP 
respiratory gaseous exchangePISS 
transportPIEA IEA 
fluid secretionPTAS 
response to peptide hormone stimulusPIEP 
response to drugPIEP 
vasodilationPIMP 
transepithelial chloride transportPIMP 
ion transportPIEA IEA IEA IEA 
response to estrogen stimulusPIEP 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (15)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
craniofacial phenotypeMPUn
behavior/neurological phenotypeMPUn Un
endocrine/exocrine gland phenotypeMPUn Un Un Un Un
homeostasis/metabolism phenotypeMPUn Un
immune system phenotypeMPUn Un Un Un Un
lethality-postnatalMPUn Un Un Un Un Un Un
respiratory system phenotypeMPUn Un Un Un Un Un Un Un
vision/eye phenotypeMPUn Un
normal phenotypeMPUn
digestive/alimentary phenotypeMPUn Un Un Un Un Un Un Un Un Un Un
hematopoietic system phenotypeMPUn
reproductive system phenotypeMPUn Un Un
life span-post-weaning/agingMPUn Un Un Un
growth/size phenotypeMPUn Un Un Un Un Un Un Un
liver/biliary system phenotypeMPUn Un Un Un

Disease (3)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
CholestasisDIEP
Duodenal UlcerDIED
Myocardial IschemiaDIEP

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (1)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
ABC transporters - General (02010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway