IpiRecord: IPI00307223

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
extracellular region	C	NAS	IEA	IMP ISS IEA
extracellular space	C	TAS	IEA	ISS IEA
growth factor activity	F		IEA IEA
signal transducer activity	F	TAS		ISS
interleukin-1 receptor binding	F	NAS	IEA	ISS IEA
protein binding	F	IPI		IEA
cytokine activity	F		IDA IDA	TAS ISS
neutrophil chemotaxis	P	IEA	IDA	ISS IEA
inflammatory response	P	NAS	IEA IEA	IEP IEA
leukocyte migration	P	IEA	IDA	ISS IEA
positive regulation of interleukin-6 production	P	IEA	IDA
positive regulation of chemokine biosynthetic process	P	IEA	IDA	ISS IEA
positive regulation of interleukin-6 biosynthetic process	P	IEA	IDA	ISS IEA
cytokine and chemokine mediated signaling pathway	P			IEP
negative regulation of cell proliferation	P	TAS		ISS
regulation of progression through cell cycle	P	IEA	IEA	IEA
immune response	P	IEA	IEA	IEA
positive regulation of JNK cascade	P	IEA	IDA IGI
cell proliferation	P	IEA	IEA	IEA
cell-cell signaling	P	TAS		ISS
apoptosis	P	TAS		ISS
fever	P	IEA	IEA	IEA
angiogenesis	P			IMP
positive regulation of I-kappaB kinase/NF-kappaB cascade	P	IEA	IDA IGI
elevation of cytosolic calcium ion concentration	P			IDA
signal transduction	P	TAS TAS		ISS

Cellular Component

Biological Process

Molecular Function

Phenotype (2)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
immune system phenotype	MP		Un
growth/size phenotype	MP		Un

Disease (30)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
??	B			IEP
AIDS Dementia Complex	D			IEP
Shock, Hemorrhagic	D			IEP
Brain Injuries	D			IEP
Sepsis	D			IEP
Inflammation	D			IEPIEP
Obesity	D			ISS
Hypercholesterolemia	D			ISS
Alzheimer Disease	D			ISS
Spinal Cord Injuries	D			IEP
Fever	D			IEP
Fatty Liver	D			IEP
Diabetes Mellitus, Experimental	D			IEP
Insulin Resistance	D			ISS
Hypolipoproteinemia	D			ISS
Hyperalgesia	D			IED
Status Epilepticus	D			IEP
Arteriosclerosis	D			ISSIEPISS
Hypertension, Portal	D			IEP
Dementia, Vascular	D			ISS
Cachexia	D			IED
Myocardial Reperfusion Injury	D			IEP
Arthritis, Experimental	D			IED
Hyperglycemia	D			IEP
Reperfusion Injury	D			IEP
Coronary Disease	D			ISS
Endotoxemia	D			IEP
Seizures, Febrile	D			IED
Parkinsonian Disorders	D			IMP
Hypertension	D			ISSIEP

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (7)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Alzheimer's disease (05010)	Present in KEGG pathway	Not present in KEGG pathway	Not present in KEGG pathway
Toll-like receptor signaling pathway (04620)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Apoptosis (04210)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
MAPK signaling pathway (04010)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Hematopoietic cell lineage (04640)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Type I diabetes mellitus (04940)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Cytokine-cytokine receptor interaction (04060)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway