IpiRecord: IPI00385374

IPI00385374 - IRAK4, INTERLEUKIN-1 RECEPTOR ASSOCIATED KINASE 4 MUTANT FORM 2.
Uniprot Accession: Q7Z6A7
Uniprot ID: Q7Z6A7_HUMAN
Mapping: Chr 12, 42439067 - 42468164
Entrez Gene: 51135
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7458)
Rat: Irak4_predicted, 22 KDA PROTEIN.
Mouse: Irak4, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4.
Mouse: Irak4, KINASE 1, FULL INSERT SEQUENCE.
Mouse: Irak4, KINASE 4, FULL INSERT SEQUENCE.
Rat: Irak4_predicted, SIMILAR TO INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4.
Human: IRAK4, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4.
Human: IRAK4, INTERLEUKIN-1 RECEPTOR ASSOCIATED KINASE 4 MUTANT FORM 2.
Human: IRAK4, KINASE APK1A (FRAGMENT).

Annotations for IRAK4 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cellular_componentCND 
protein-tyrosine kinase activityFIEA 
kinase activityFIEA IEA 
nucleotide bindingFIEA IEA 
protein bindingFIPI IPI IEA IEA IEA 
protein serine/threonine kinase activityFIEA IEA IEA 
magnesium ion bindingFIEA IEA 
ATP bindingFIEA IEA IEA IEA 
interleukin-1 receptor bindingFIPI ISS 
transferase activityFIEA IEA 
protein kinase activityFIEA IEA 
molecular_functionFND 
receptor activityFIEA IEA 
protein amino acid phosphorylationPIEA IEA IEA 
cytokine productionPIDA ISS 
cytokine and chemokine mediated signaling pathwayPIDA IMP ISS 
signal transductionPIEA IEA 
positive regulation of smooth muscle cell proliferationPIMP 
JNK cascadePIMP 
positive regulation of transcription from RNA polymerase II promoterPIMP 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (3)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn
immune system phenotypeMPUn Un
tumorigenesisMPUn

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Bacterial Infections and MycosesDISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Toll-like receptor signaling pathway (04620)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Apoptosis (04210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway