IpiRecord: IPI00394952

IPI00394952 - LCK, ISOFORM LONG OF PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK.
Uniprot Accession: Q7RTZ3
Uniprot ID: Q7RTZ3_HUMAN
Mapping: Chr 1, 32489480 - 32524353
Entrez Gene: 3932
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_5808)
Rat: Lck, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK (FRAGMENT).
Mouse: Lck, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK.
Mouse: Lck, LYMPHOCYTE PROTEIN TYROSINE KINASE.
Rat: Lck, SIMILAR TO LYMPHOCYTE PROTEIN TYROSINE KINASE.
Rat: Lck, SIMILAR TO LYMPHOCYTE PROTEIN TYROSINE KINASE.
Human: LCK, ISOFORM LONG OF PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK.
Human: LCK, ISOFORM SHORT OF PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK.
Human: LCK, ISOFORM 3 OF PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK.
Human: LCK, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK.

Annotations for LCK and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmCIEA 
endocytic vesicleCIDA 
plasma membraneCIDA 
membraneCIEA IEA 
ATP bindingFIEA IEA IEA IEA 
protein-tyrosine kinase activityFIEA IDA IDA IEA 
protein complex bindingFIDA 
protein serine/threonine kinase activityFISS 
protein kinase activityFIEA ISS 
kinase activityFIEA IEA 
protein bindingFIPI IPI 
transferase activityFIEA IEA 
nucleotide bindingFIEA IEA 
protein amino acid autophosphorylationPIDA 
apoptosisPIEP 
protein amino acid phosphorylationPIEA IDA IEA 
response to hydrogen peroxidePIDA 
intracellular signaling cascadePIEA IEA IEA 
peptidyl-tyrosine phosphorylationPIDA 
release of sequestered calcium ion into cytosolPIDA 
regulation of T cell receptor signaling pathwayPIDA ISS 
response to metal ionPIDA 
agingPIEP 
T cell activationPISS 
response to zinc ionPIEP 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (2)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
immune system phenotypeMPUn Un
hematopoietic system phenotypeMPUn

Disease (2)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
HIV InfectionsDIED
Conjunctivitis, AllergicDIED

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
T cell receptor signaling pathway (04660)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Natural killer cell mediated cytotoxicity (04650)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway