IpiRecord: IPI00413641

IPI00413641 - AKR1B1, ALDOSE REDUCTASE.
Uniprot Accession: Q6ICP2
Uniprot ID: Q6ICP2_HUMAN
Mapping: Chr 7, 133777649 - 133794428
Entrez Gene: 231
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4390)
Rat: Akr1b4, ALDOSE REDUCTASE.
Mouse: Akr1b3, ALDOSE REDUCTASE.
Mouse: Akr1b3, (ALDOSE REDUCTASE), FULL INSERT SEQUENCE.
Mouse: Akr1b3, 20 KDA PROTEIN.
Human: AKR1B1, ALDOSE REDUCTASE.
Human: AKR1B1, ALDO-KETO REDUCTASE FAMILY 1, MEMBER B1 VARIANT (FRAGMENT).

Annotations for AKR1B1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
extracellular spaceCTAS IDA ISS 
cytoplasmCIEA IEA 
aldehyde reductase activityFTAS IEA IDA ISS ISS IEA 
protein bindingFIPI 
electron carrier activityFTAS ISS 
oxidoreductase activityFIEA IEA IEA IEA 
positive regulation of JAK-STAT cascadePIMP 
stress-activated protein kinase signaling pathwayPIMP 
carbohydrate metabolic processPTAS ISS 
sorbitol biosynthetic processPIMP 
response to organic substancePIDA 
response to stressPTAS 
positive regulation of smooth muscle cell proliferationPIMP 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (4)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
homeostasis/metabolism phenotypeMPUn
behavior/neurological phenotypeMPUn
renal/urinary system phenotypeMPUn Un
growth/size phenotypeMPUn

Disease (11)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
HyperalgesiaDIED
InflammationDISS
CataractDIED
GalactosemiasDIEP
ArteriosclerosisDIED
Myocardial IschemiaDIED
Diabetic NeuropathiesDIED
HypersensitivityDIED
Diabetic RetinopathyDIED
HyperglycemiaDIEP
HypokalemiaDIEP

Pathway (7)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
diabetic nephropathy pathwayWISS
altered galactose metabolic pathwayWISS
galactose metabolic pathwayWIEA
glycerolipid metabolic pathwayWIEA
pentose and glucuronate interconversion pathwayWIEA
pyruvate metabolic pathwayWIEA
fructose and mannose metabolic pathwayWIEA

KEGG Pathway (5)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Pentose and glucuronate interconversions (00040)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Fructose and mannose metabolism (00051)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Galactose metabolism (00052)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Glycerolipid metabolism (00561)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pyruvate metabolism (00620)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway