| IPI00413641 - AKR1B1, ALDOSE REDUCTASE. | |
|---|---|
| Uniprot Accession: Q6ICP2 | |
| Uniprot ID: Q6ICP2_HUMAN | |
| Mapping: Chr 7, 133777649 - 133794428 | |
| Entrez Gene: 231 | |
| Entrez MapView: |
|
| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4390) |
|---|
| Rat: Akr1b4, ALDOSE REDUCTASE. |
| Mouse: Akr1b3, ALDOSE REDUCTASE. |
| Mouse: Akr1b3, (ALDOSE REDUCTASE), FULL INSERT SEQUENCE. |
| Mouse: Akr1b3, 20 KDA PROTEIN. |
| Human: AKR1B1, ALDOSE REDUCTASE. |
| Human: AKR1B1, ALDO-KETO REDUCTASE FAMILY 1, MEMBER B1 VARIANT (FRAGMENT). |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| extracellular space | C | TAS | IDA ISS | |
| cytoplasm | C | IEA | IEA | |
| aldehyde reductase activity | F | TAS | IEA | IDA ISS ISS IEA |
| protein binding | F | IPI | ||
| electron carrier activity | F | TAS | ISS | |
| oxidoreductase activity | F | IEA | IEA IEA | IEA |
| positive regulation of JAK-STAT cascade | P | IMP | ||
| stress-activated protein kinase signaling pathway | P | IMP | ||
| carbohydrate metabolic process | P | TAS | ISS | |
| sorbitol biosynthetic process | P | IMP | ||
| response to organic substance | P | IDA | ||
| response to stress | P | TAS | ||
| positive regulation of smooth muscle cell proliferation | P | IMP |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| homeostasis/metabolism phenotype | MP | Un | ||
| behavior/neurological phenotype | MP | Un | ||
| renal/urinary system phenotype | MP | Un Un | ||
| growth/size phenotype | MP | Un |
| DO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Hyperalgesia | D | IED | ||
| Inflammation | D | ISS | ||
| Cataract | D | IED | ||
| Galactosemias | D | IEP | ||
| Arteriosclerosis | D | IED | ||
| Myocardial Ischemia | D | IED | ||
| Diabetic Neuropathies | D | IED | ||
| Hypersensitivity | D | IED | ||
| Diabetic Retinopathy | D | IED | ||
| Hyperglycemia | D | IEP | ||
| Hypokalemia | D | IEP |
| PW Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| diabetic nephropathy pathway | W | ISS | ||
| altered galactose metabolic pathway | W | ISS | ||
| galactose metabolic pathway | W | IEA | ||
| glycerolipid metabolic pathway | W | IEA | ||
| pentose and glucuronate interconversion pathway | W | IEA | ||
| pyruvate metabolic pathway | W | IEA | ||
| fructose and mannose metabolic pathway | W | IEA |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| Pentose and glucuronate interconversions (00040) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Fructose and mannose metabolism (00051) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Galactose metabolism (00052) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Glycerolipid metabolism (00561) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Pyruvate metabolism (00620) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |