IpiRecord: IPI00514814

IPI00514814 - AKR1C1, ALDO-KETO REDUCTASE FAMILY 1, MEMBER C1.
Uniprot Accession: Q5SR14
Uniprot ID: Q5SR14_HUMAN
Mapping: Chr 10, 4995445 - 5012159
Entrez Gene: 1645
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_13345)
Rat: Akr1c6, ALDO-KETO REDUCTASE FAMILY 1, MEMBER C6.
Mouse: Akr1c6, ESTRADIOL 17 BETA-DEHYDROGENASE 5.
Human: AKR1C1, ALDO-KETO REDUCTASE FAMILY 1 MEMBER C1.
Human: AKR1C1, ALDO-KETO REDUCTASE FAMILY 1, MEMBER C1.
Human: AKR1C1, UNCHARACTERIZED PROTEIN AKR1C1.

Annotations for AKR1C1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmCIEA 
cellular_componentCND 
cytosolCIDA ISS 
20-alpha-hydroxysteroid dehydrogenase activityFIEA 
aldo-keto reductase activityFTAS ISS 
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activityFIDA ISS 
bile acid bindingFIDA 
3-alpha-hydroxysteroid dehydrogenase (B-specific) activityFIDA ISS 
carboxylic acid bindingFISS 
oxidoreductase activityFIEA RCA ISS IEA 
estradiol 17-beta-dehydrogenase activityFIDA ISS IEA 
digestionPIDA ISS 
lipid biosynthetic processPIEA 
bile acid metabolic processPIDA ISS 
cholesterol homeostasisPTAS ISS 
steroid metabolic processPIDA ISS 
steroid biosynthetic processPRCA ISS 
protein homooligomerizationPIDA ISS 
xenobiotic metabolic processPNAS ISS 
bile acid and bile salt transportPTAS ISS 
cholesterol absorptionPTAS ISS 
electron transportPIDA ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (0)

There are no Mammalian Phenotype Ontology annotations for this protein in the database

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
ObesityDISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Metabolism of xenobiotics by cytochrome P450 (00980)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Glycine, serine and threonine metabolism (00260)Not present in KEGG pathwayPresent in KEGG pathwayNot present in KEGG pathway
Fructose and mannose metabolism (00051)Not present in KEGG pathwayPresent in KEGG pathwayNot present in KEGG pathway
Bisphenol A degradation (00363)Not present in KEGG pathwayPresent in KEGG pathwayNot present in KEGG pathway
Lysine degradation (00310)Not present in KEGG pathwayPresent in KEGG pathwayNot present in KEGG pathway
Galactose metabolism (00052)Not present in KEGG pathwayPresent in KEGG pathwayNot present in KEGG pathway
Tetrachloroethene degradation (00625)Not present in KEGG pathwayPresent in KEGG pathwayNot present in KEGG pathway
Linoleic acid metabolism (00591)Not present in KEGG pathwayPresent in KEGG pathwayNot present in KEGG pathway
Bile acid biosynthesis (00120)Not present in KEGG pathwayPresent in KEGG pathwayNot present in KEGG pathway
Butanoate metabolism (00650)Not present in KEGG pathwayPresent in KEGG pathwayNot present in KEGG pathway