IpiRecord: IPI00783674

IPI00783674 - ZAP70, TYROSINE-PROTEIN KINASE ZAP-70.
Uniprot Accession: Q6PIA4
Uniprot ID: Q6PIA4_HUMAN
Mapping: Chr 2, 97696461 - 97722755
Entrez Gene: 7535
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_8715)
Rat: Zap70, ZETA-CHAIN (TCR) ASSOCIATED PROTEIN KINASE 70.
Mouse: Zap70, TYROSINE-PROTEIN KINASE ZAP-70.
Mouse: Zap70, TYROSINE KINASE.
Mouse: Zap70, TRUNCATED ZAP KINASE-2.
Rat: Zap70, 35 KDA PROTEIN.
Human: ZAP70, UNCHARACTERIZED PROTEIN ZAP70.
Human: ZAP70, ZETA-CHAIN ASSOCIATED PROTEIN KINASE 70KDA ISOFORM 2.
Human: ZAP70, TYROSINE-PROTEIN KINASE ZAP-70.

Annotations for ZAP70 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
T cell receptor complexCIDA ISS 
cytoplasmCIEA TAS IEA IEA 
cytosolCIDA ISS 
cellular_componentCND 
nucleotide bindingFIEA IEA IEA 
protein bindingFIPI IPI IPI IPI ISS ISS 
protein kinase activityFIDA ISS 
kinase activityFIEA 
molecular_functionFND 
ATP bindingFIEA NAS IDA ISS IEA 
non-membrane spanning protein tyrosine kinase activityFIEA IEA IEA 
protein-tyrosine kinase activityFIEA IDA IMP IDA ISS 
transferase activityFIEA IEA IEA 
phosphotyrosine bindingFIPI ISS 
positive regulation of alpha-beta T cell proliferationPIGI ISS 
intracellular signaling cascadePIEA IMP ISS IEA 
beta selectionPIGI 
protein amino acid autophosphorylationPIDA IMP ISS 
T cell receptor signaling pathwayPIMP ISS 
peptidyl-tyrosine phosphorylationPIDA IMP ISS 
protein amino acid phosphorylationPIEA NAS IDA IEA 
positive regulation of calcium-mediated signalingPIMP IMP ISS 
negative thymic T cell selectionPIMP ISS 
thymic T cell selectionPIMP ISS 
positive regulation of alpha-beta T cell differentiationPIMP IMP IGI ISS 
positive regulation of T cell differentiationPIDA ISS IMP ISS 
protein kinase cascadePNAS 
immune responsePIDA 
positive thymic T cell selectionPIDA ISS IMP ISS 
biological_processPND 
signal transductionPIEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (6)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
skin/coat/nails phenotypeMPUn
immune system phenotypeMPUn Un Un Un Un
skeleton phenotypeMPUn Un
respiratory system phenotypeMPUn
normal phenotypeMPUn Un
hematopoietic system phenotypeMPUn Un Un Un Un

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Severe Combined ImmunodeficiencyDISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
T cell receptor signaling pathway (04660)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Natural killer cell mediated cytotoxicity (04650)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway