| IPI00783674 - ZAP70, TYROSINE-PROTEIN KINASE ZAP-70. | |
|---|---|
| Uniprot Accession: Q6PIA4 | |
| Uniprot ID: Q6PIA4_HUMAN | |
| Mapping: Chr 2, 97696461 - 97722755 | |
| Entrez Gene: 7535 | |
| Entrez MapView: |
|
| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_8715) |
|---|
| Rat: Zap70, ZETA-CHAIN (TCR) ASSOCIATED PROTEIN KINASE 70. |
| Mouse: Zap70, TYROSINE-PROTEIN KINASE ZAP-70. |
| Mouse: Zap70, TYROSINE KINASE. |
| Mouse: Zap70, TRUNCATED ZAP KINASE-2. |
| Rat: Zap70, 35 KDA PROTEIN. |
| Human: ZAP70, UNCHARACTERIZED PROTEIN ZAP70. |
| Human: ZAP70, ZETA-CHAIN ASSOCIATED PROTEIN KINASE 70KDA ISOFORM 2. |
| Human: ZAP70, TYROSINE-PROTEIN KINASE ZAP-70. |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| T cell receptor complex | C | IDA | ISS | |
| cytoplasm | C | IEA TAS | IEA | IEA |
| cytosol | C | IDA | ISS | |
| cellular_component | C | ND | ||
| nucleotide binding | F | IEA | IEA | IEA |
| protein binding | F | IPI IPI IPI IPI | ISS ISS | |
| protein kinase activity | F | IDA | ISS | |
| kinase activity | F | IEA | ||
| molecular_function | F | ND | ||
| ATP binding | F | IEA NAS | IDA | ISS IEA |
| non-membrane spanning protein tyrosine kinase activity | F | IEA | IEA | IEA |
| protein-tyrosine kinase activity | F | IEA | IDA IMP IDA | ISS |
| transferase activity | F | IEA | IEA | IEA |
| phosphotyrosine binding | F | IPI | ISS | |
| positive regulation of alpha-beta T cell proliferation | P | IGI | ISS | |
| intracellular signaling cascade | P | IEA | IMP | ISS IEA |
| beta selection | P | IGI | ||
| protein amino acid autophosphorylation | P | IDA IMP | ISS | |
| T cell receptor signaling pathway | P | IMP | ISS | |
| peptidyl-tyrosine phosphorylation | P | IDA IMP | ISS | |
| protein amino acid phosphorylation | P | IEA NAS | IDA | IEA |
| positive regulation of calcium-mediated signaling | P | IMP IMP | ISS | |
| negative thymic T cell selection | P | IMP | ISS | |
| thymic T cell selection | P | IMP | ISS | |
| positive regulation of alpha-beta T cell differentiation | P | IMP IMP IGI | ISS | |
| positive regulation of T cell differentiation | P | IDA | ISS IMP | ISS |
| protein kinase cascade | P | NAS | ||
| immune response | P | IDA | ||
| positive thymic T cell selection | P | IDA | ISS IMP | ISS |
| biological_process | P | ND | ||
| signal transduction | P | IEA |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| skin/coat/nails phenotype | MP | Un | ||
| immune system phenotype | MP | Un Un Un Un Un | ||
| skeleton phenotype | MP | Un Un | ||
| respiratory system phenotype | MP | Un | ||
| normal phenotype | MP | Un Un | ||
| hematopoietic system phenotype | MP | Un Un Un Un Un |
| DO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Severe Combined Immunodeficiency | D | ISS |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| T cell receptor signaling pathway (04660) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Natural killer cell mediated cytotoxicity (04650) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |