IpiRecord: IPI00793270

IPI00793270 - PTK2, PTK2 PROTEIN.
Uniprot Accession: Q8IYN9
Uniprot ID: Q8IYN9_HUMAN
Mapping: Chr 8, 141737683 - 142080514
Entrez Gene: 5747
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7347)
Rat: Ptk2, 58 KDA PROTEIN.
Mouse: Ptk2, ISOFORM 1 OF FOCAL ADHESION KINASE 1.
Mouse: Ptk2, ISOFORM 2 OF FOCAL ADHESION KINASE 1.
Mouse: Ptk2, FOCAL ADHESION KINASE SPLICED VARIANT P110FAK.
Mouse: Ptk2, FOCAL ADHESION KINASE.
Mouse: Ptk2, SEQUENCE.
Rat: Ptk2, FOCAL ADHESION KINASE 1.
Rat: Ptk2, 124 KDA PROTEIN.
Human: PTK2, ISOFORM 1 OF FOCAL ADHESION KINASE 1.
Human: PTK2, ISOFORM 3 OF FOCAL ADHESION KINASE 1.
Human: PTK2, ISOFORM 4 OF FOCAL ADHESION KINASE 1.
Human: PTK2, PTK2 PROTEIN TYROSINE KINASE 2 ISOFORM B.
Human: PTK2, PTK2 PROTEIN TYROSINE KINASE 2 ISOFORM B VARIANT.
Human: PTK2, PTK2 PROTEIN.
Human: PTK2, 14 KDA PROTEIN.

Annotations for PTK2 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cell junctionCIEA 
cytoskeletonCIEA IEA ISS IEA 
apical plasma membraneCIDA 
lamellipodiumCIDA ISS 
focal adhesionCIEA IDA IDA IDA IDA TAS ISS 
protein serine/threonine kinase activityFISS 
ATP bindingFIEA IEA IEA IEA 
protein bindingFIPI IPI ISS ISS IDA 
kinase activityFIEA 
protein-tyrosine kinase activityFIEA IEA IEA TAS ISS IEA 
protein kinase activityFIEA 
SH2 domain bindingFISS 
transferase activityFIEA IEA IEA 
signal transducer activityFIEA 
nucleotide bindingFIEA IEA IEA 
establishment of nucleus localizationPIDA ISS 
neuron migrationPIDA IMP ISS 
extracellular matrix organization and biogenesisPIMP ISS 
cell motilityPTAS ISS 
protein amino acid phosphorylationPIEA IEA ISS IEA 
microtubule cytoskeleton organization and biogenesisPIDA ISS 
endothelial cell migrationPIMP 
angiogenesisPIMP 
integrin-mediated signaling pathwayPTAS ISS ISS 
negative regulation of organ sizePIGI ISS 
signal complex assemblyPIEA 
blood vessel developmentPIMP IMP ISS 
vasculogenesisPIMP 
protein amino acid autophosphorylationPIMP 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (15)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn Un Un
skin/coat/nails phenotypeMPUn Un Un Un
endocrine/exocrine gland phenotypeMPUn Un
homeostasis/metabolism phenotypeMPUn
immune system phenotypeMPUn
embryogenesis phenotypeMPUn Un Un
lethality-embryonic/perinatalMPUn Un Un
muscle phenotypeMPUn Un
nervous system phenotypeMPUn Un
tumorigenesisMPUn
digestive/alimentary phenotypeMPUn
normal phenotypeMPUn Un
cardiovascular system phenotypeMPUn Un Un
hematopoietic system phenotypeMPUn
growth/size phenotypeMPUn Un Un

Disease (2)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Hypertension, PulmonaryDISS
HypertensionDIAGP

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
VEGF signaling pathway (04370)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Leukocyte transendothelial migration (04670)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Regulation of actin cytoskeleton (04810)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Axon guidance (04360)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Focal adhesion (04510)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway