IpiRecord: IPI00793994

IPI00793994 - IGF1, INSULIN-LIKE GROWTH FACTOR I PRECURSOR.
Uniprot Accession: Q9NP10
Uniprot ID: Q9NP10_HUMAN
Mapping: Chr 12, 101313809 - 101398471
Entrez Gene: 3479
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_6895)
Rat: Igf1, ISOFORM IGF-IA OF INSULIN-LIKE GROWTH FACTOR I PRECURSOR.
Mouse: Igf1, ISOFORM IGF-IA OF INSULIN-LIKE GROWTH FACTOR I PRECURSOR.
Mouse: Igf1, ISOFORM IGF-IB OF INSULIN-LIKE GROWTH FACTOR I PRECURSOR.
Mouse: Igf1, SEQUENCE.
Mouse: Igf1, INSULIN-LIKE GROWTH FACTOR 1 ISOFORM EB.
Rat: Igf1, 15 KDA PROTEIN.
Rat: Igf1, INSULIN-LIKE GROWTH FACTOR 1 ISOFORM C.
Rat: Igf1, INSULIN-LIKE GROWTH FACTOR 1 ISOFORM B.
Rat: Igf1, INSULIN-LIKE GROWTH FACTOR 1 ISOFORM A.
Human: IGF1, INSULIN-LIKE GROWTH FACTOR IA PRECURSOR.
Human: IGF1, INSULIN-LIKE GROWTH FACTOR IB PRECURSOR.
Human: IGF1, INSULIN-LIKE GROWTH FACTOR I PRECURSOR.
Human: IGF1, 3 KDA PROTEIN.
Human: IGF1, 15 KDA PROTEIN.
Human: IGF1, INSULIN-LIKE GROWTH FACTOR-I.
Human: IGF1, 18 KDA PROTEIN.

Annotations for IGF1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
interstitial matrixCIDA 
extracellular spaceCIDA IDA ISS 
extracellular regionCNAS IEA IEA ISS IEA 
insulin-like growth factor receptor bindingFTAS IPI ISS ISS IDA 
hormone activityFTAS IEA IEA ISS IDA IEA 
steroid bindingFIDA 
growth factor activityFIEA IEA TAS 
protein bindingFIPI IPI ISS IPI 
prothoracicotrophic hormone activityFIEA IEA IEA 
female pregnancyPIEP 
insulin-like growth factor receptor signaling pathwayPIC IDA ISS IDA 
positive regulation of anti-apoptosisPIDA 
regulation of cell proliferationPIDA 
mammary gland developmentPIMP 
positive regulation of cell proliferationPTAS ISS 
memoryPIMP 
regulation of steroid hormone receptor signaling pathwayPIDA ISS 
anti-apoptosisPIDA ISS 
multicellular organism growthPIDA 
nervous system developmentPIMP ISS 
signal transductionPTAS ISS 
positive regulation of calcium ion transport via voltage gated calcium channelPIDA 
DNA replicationPTAS ISS 
water homeostasisPIGI 
positive regulation of granule cell precursor proliferationPIDA 
response to steroid hormone stimulusPIEP 
organ morphogenesisPIMP ISS 
positive regulation of cell growthPIDA IMP 
muscle developmentPTAS ISS 
cell motilityPTAS ISS 
branching morphogenesis of a tubePIMP 
glial cell differentiationPIMP ISS 
cell developmentPIMP ISS 
positive regulation of osteoblast differentiationPIDA 
Ras protein signal transductionPTAS ISS 
regulation of protein metabolic processPIGI 
positive regulation of fat cell differentiationPIDA 
regulation of translationPIMP 
response to mechanical stimulusPIEP 
glycolate metabolic processPTAS ISS 
skeletal developmentPTAS ISS 
sensory perception of soundPIEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (15)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
skin/coat/nails phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
growth/size phenotypeMPUn Un Un Un
other phenotypeMPUn
lethality-embryonic/perinatalMPUn Un Un
muscle phenotypeMPUn Un
skeleton phenotypeMPUn Un
hearing/vestibular/ear phenotypeMPUn
nervous system phenotypeMPUn Un
respiratory system phenotypeMPUn Un
cardiovascular system phenotypeMPUn
limbs/digits/tail phenotypeMPUn
normal phenotypeMPUn
lethality-postnatalMPUn
cardiac hypertrophyNIED

Disease (16)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Rheumatic Heart DiseaseDISS
Cardiomyopathy, HypertrophicDISS
Carotid Artery DiseasesDISS
Growth DisordersDISS
Myocardial InfarctionDISS
Cerebrovascular AccidentDISSIEP
Dementia, VascularDISS
Brain IschemiaDIED
Cardiomyopathy, CongestiveDISS
Myocardial IschemiaDISSIED
Diabetic RetinopathyDISS
Coronary DiseaseDISS
Reperfusion InjuryDISS
Heart Failure, CongestiveDIEP
AlbuminuriaDISS
HypertensionDIAGP

Pathway (5)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
phosphatidylinositol 3 kinase-Akt signaling pathwayWISSIMP
insulin-like growth factor signaling pathwayWISSIDA
p38 MAPK pathwayWIMP
cardiovascular disease pathwayWIEP
altered insulin-like growth factor signaling pathwayWIEP

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Glioma (05214)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Long-term depression (04730)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
mTOR signaling pathway (04150)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Focal adhesion (04510)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway