IpiRecord: IPI00796188

IPI00796188 - TP53, CELLULAR TUMOR ANTIGEN P53 (FRAGMENT).
Uniprot Accession: Q0ZAK1
Uniprot ID: Q0ZAK1_HUMAN
Mapping: Chr 17, 7512464 - 7531642
Entrez Gene: 7157
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_9697)
Rat: Tp53, CELLULAR TUMOR ANTIGEN P53.
Mouse: Trp53, CELLULAR TUMOR ANTIGEN P53.
Mouse: Trp53, CELLULAR TUMOR ANTIGEN P53.
Rat: Tp53, CELLULAR TUMOR ANTIGEN P53.
Rat: Tp53, MUTANT P53.
Rat: Tp53, CELLULAR TUMOR ANTIGEN P53.
Human: TP53, ISOFORM 1 OF CELLULAR TUMOR ANTIGEN P53.
Human: TP53, ISOFORM 2 OF CELLULAR TUMOR ANTIGEN P53.
Human: TP53, CELLULAR TUMOR ANTIGEN P53.
Human: TP53, CELLULAR TUMOR ANTIGEN P53 (FRAGMENT).
Human: TP53, CELLULAR TUMOR ANTIGEN P53 (FRAGMENT).
Human: TP53, P53-EX10 ISOFORM (FRAGMENT).

Annotations for TP53 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
replication forkCIDA ISS 
cytoplasmCIDA IDA IDA ISS ISS ISS IMP ISS 
endoplasmic reticulumCIEA IEA 
mitochondrionCISS ISS 
nucleolusCISS ISS 
nucleoplasmCISS 
nuclear matrixCISS 
cytosolCIDA ISS 
nucleusCIEA IDA IDA IDA ISS IDA ISS ISS IMP IEA ISS 
insoluble fractionCISS 
enzyme bindingFISS 
protein N-terminus bindingFISS 
ATP bindingFISS ISS 
transcription factor activityFIEA IDA IDA IDA ISS ISS IEA 
RNA polymerase II transcription factor activityFTAS 
chromatin bindingFISS 
nuclease activityFISS 
protein bindingFIPI IPI IPI IPI IPI IPI IPI IPI IPI IPI IPI ISS ISS IPI 
copper ion bindingFISS ISS 
zinc ion bindingFIEA IEA ISS IEA 
DNA bindingFIDA IDA IDA IDA ISS 
metal ion bindingFIEA IEA IEA 
protein heterodimerization activityFISS 
DNA strand annealing activityFISS ISS 
cell cyclePIEA IEA IEA 
central nervous system developmentPIGI 
response to DNA damage stimulusPIDA IMP ISS IDA ISS ISS 
cellular response to glucose starvationPISS 
cell agingPISS ISS 
cell proliferationPISS 
positive regulation of transcriptionPIDA IGI ISS 
induction of apoptosisPIDA IMP ISS 
negative regulation of apoptosisPIMP ISS 
multicellular organismal developmentPISS 
regulation of mitochondrial membrane permeabilityPISS 
regulation of progression through cell cyclePIMP ISS 
base-excision repairPISS 
cell differentiationPISS 
response to gamma radiationPIDA 
embryonic development ending in birth or egg hatchingPIGI ISS 
negative regulation of neuroblast proliferationPIGI 
negative regulation of cell growthPTAS ISS ISS 
response to UVPIMP IDA ISS 
in utero embryonic developmentPIGI IGI 
negative regulation of cell proliferationPIGI IGI IGI IGI 
positive regulation of transcription from RNA polymerase II promoterPIDA IDA ISS ISS 
cell cycle arrestPISS 
G1 DNA damage checkpointPIMP ISS 
regulation of cell proliferationPIMP ISS 
caspase activation via cytochrome cPISS ISS 
transcriptionPIEA IEA 
apoptosisPIEA IGI IDA ISS ISS IEA ISS 
nucleotide-excision repairPISS ISS 
positive regulation of neuron apoptosisPIMP IDA IMP IGI 
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisPIMP ISS ISS IGI ISS ISS 
regulation of transcription, DNA-dependentPIEA IDA ISS ISS 
regulation of apoptosisPISS 
protein tetramerizationPISS 
response to X-rayPIDA ISS 
protein import into nucleus, translocationPIDA ISS 
negative regulation of progression through cell cyclePIEA IEA IEA 
positive regulation of transcription, DNA-dependentPIDA 
positive regulation of apoptosisPIMP 
ER overload responsePISS 
regulation of neuron apoptosisPIGI 
protein complex assemblyPISS 
regulation of cellular pHPIMP 
release of cytochrome c from mitochondriaPIDA 
negative regulation of fibroblast proliferationPIMP ISS 
negative regulation of DNA replicationPIDA IMP ISS 
negative regulation of helicase activityPISS 
DNA damage response, signal transduction by p53 class mediatorPIGI IGI IDA IDA ISS 
regulation of transcription from RNA polymerase II promoterPTAS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (27)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
craniofacial phenotypeMP#
skin/coat/nails phenotypeMP#######
cellular phenotypeMP#####################
homeostasis/metabolism phenotypeMP#
behavior/neurological phenotypeMP#
endocrine/exocrine gland phenotypeMP###
immune system phenotypeMP###
embryogenesis phenotypeMP#####
lethality-embryonic/perinatalMP#############
muscle phenotypeMP#
skeleton phenotypeMP####
lethality-postnatalMP#
renal/urinary system phenotypeMP#
growth/size phenotypeMP#####
respiratory system phenotypeMP##
vision/eye phenotypeMP##
tumorigenesisMP####################
digestive/alimentary phenotypeMP#
normal phenotypeMP###
cardiovascular system phenotypeMP####
life span-post-weaning/agingMP############
hematopoietic system phenotypeMP##
reproductive system phenotypeMP###
no phenotypic analysisMP#
nervous system phenotypeMP###
abnormal apoptosisNISS
increased tumor incidenceNISS

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Coronary RestenosisDISS

Pathway (6)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
Wnt signaling pathwayWIEA
programmed cell death pathwayWIEA
amyotrophic lateral sclerosis disease pathwayWIEA
p53-dependent G1/S DNA damage checkpoint pathwayWIEA
mitogen activated protein kinase signaling pathwayWIEA
Huntington disease pathwayWIEA

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Glioma (05214)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Chronic myeloid leukemia (05220)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cell cycle (04110)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Apoptosis (04210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
MAPK signaling pathway (04010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Amyotrophic lateral sclerosis (ALS) (05030)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Wnt signaling pathway (04310)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Colorectal cancer (05210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Huntington's disease (05040)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pancreatic cancer (05212)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway