IpiRecord: IPI00854859

IPI00854859 - MAPK8, MITOGEN-ACTIVATED PROTEIN KINASE 8 TRANSCRIPT VARIANT 2.
Uniprot Accession: Q308M2
Uniprot ID: Q308M2_HUMAN
Mapping: Chr 10, 49184739 - 49317409
Entrez Gene: 5599
Entrez MapView: Geneprod
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_12629)
Rat: Mapk8, MITOGEN-ACTIVATED PROTEIN KINASE 8.
Mouse: Mapk8, MITOGEN-ACTIVATED PROTEIN KINASE 8.
Mouse: Mapk8, 48 KDA PROTEIN.
Mouse: Mapk8, JNK1 BETA1 PROTEIN KINASE.
Mouse: Mapk8, MAPK8 PROTEIN.
Mouse: Mapk8, 35 KDA PROTEIN.
Rat: Mapk8, SIMILAR TO MITOGEN-ACTIVATED PROTEIN KINASE 8.
Human: MAPK8, ISOFORM 1 OF MITOGEN-ACTIVATED PROTEIN KINASE 8.
Human: MAPK8, ISOFORM 2 OF MITOGEN-ACTIVATED PROTEIN KINASE 8.
Human: MAPK8, ISOFORM 3 OF MITOGEN-ACTIVATED PROTEIN KINASE 8.
Human: MAPK8, ISOFORM 4 OF MITOGEN-ACTIVATED PROTEIN KINASE 8.
Human: MAPK8, 16 KDA PROTEIN.
Human: MAPK8, UNCHARACTERIZED PROTEIN MAPK8.
Human: MAPK8, 11 KDA PROTEIN.
Human: MAPK8, MITOGEN-ACTIVATED PROTEIN KINASE 8 TRANSCRIPT VARIANT 2.

Annotations for MAPK8 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
proton-transporting two-sector ATPase complexCISS 
cytoplasmCIDA 
nucleusCIDA IDA 
vesicleCIDA 
MAP kinase activityFIEA RCA ISS IEA 
protein-tyrosine kinase activityFISS 
kinase activityFIDA IDA IDA ISS 
protein bindingFIPI IPI ISS ISS IPI IEA 
nucleotide bindingFIEA IEA IEA 
protein kinase activityFIEA IEA 
hydrogen ion transporting ATP synthase activity, rotational mechanismFISS 
transferase activityFIEA IEA IEA 
JUN kinase activityFIDA TAS ISS ISS ISS 
ATP bindingFIEA IEA IEA IEA 
protein serine/threonine kinase activityFIEA ISS IEA 
hydrogen ion transporting ATPase activity, rotational mechanismFISS 
ATP synthesis coupled proton transportPISS 
response to steroid hormone stimulusPIEP 
JUN phosphorylationPIMP ISS 
positive regulation of dendrite morphogenesisPISS 
inflammatory responsePIDA 
ossificationPIMP ISS IEA 
cell motilityPISS 
positive regulation of apoptosisPIEP 
response to osmotic stressPIDA 
protein amino acid phosphorylationPIEA IDA ISS IEA 
negative regulation of apoptosisPISS IDA 
peptidyl-threonine phosphorylationPIMP 
response to hydrogen peroxidePIDA 
response to stressPISS 
neurite developmentPIMP 
positive regulation of microtubule polymerizationPIMP 
regulation of transcription, DNA-dependentPIDA 
JNK cascadePISS ISS 
signal transductionPIDA ISS 
response to heatPIDA 
positive regulation of cell migrationPIDA 
response to UVPISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (20)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
adipose tissue phenotypeMPUn
skin/coat/nails phenotypeMPUn
cellular phenotypeMPUn
homeostasis/metabolism phenotypeMPUn Un
embryogenesis phenotypeMPUn
immune system phenotypeMPUn Un
lethality-embryonic/perinatalMPUn Un
lethality-postnatalMPUn Un
muscle phenotypeMPUn
renal/urinary system phenotypeMPUn
nervous system phenotypeMPUn Un
respiratory system phenotypeMPUn
vision/eye phenotypeMPUn
tumorigenesisMPUn
cardiovascular system phenotypeMPUn
digestive/alimentary phenotypeMPUn
hematopoietic system phenotypeMPUn Un
reproductive system phenotypeMPUn
growth/size phenotypeMPUn
liver/biliary system phenotypeMPUn

Disease (7)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
CardiomegalyDISS
Cerebrovascular AccidentDIED
Brain IschemiaDIED
Myocardial Reperfusion InjuryDIEPIED
Reperfusion InjuryDIED
Aortic Aneurysm, AbdominalDISS
HypertensionDIED

Pathway (2)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
inflammatory response pathwayWIDA
the planar cell polarity Wnt signaling pathwayWISS

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
GnRH signaling pathway (04912)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Epithelial cell signaling in Helicobacter pylori infection (05120)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Toll-like receptor signaling pathway (04620)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Adipocytokine signaling pathway (04920)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Fc epsilon RI signaling pathway (04664)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
MAPK signaling pathway (04010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Type II diabetes mellitus (04930)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Wnt signaling pathway (04310)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Colorectal cancer (05210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pancreatic cancer (05212)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Insulin signaling pathway (04910)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Focal adhesion (04510)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway