IpiRecord: IPI00108150

IPI00108150 - Rock2, RHO-ASSOCIATED PROTEIN KINASE 2.
Uniprot Accession: Q8CC95
Uniprot ID: Q8CC95_MOUSE
Mapping: Chr 12, 16920670 - 17003586
Entrez Gene: 19878
Entrez MapView: Geneprod
MGI: MGI:107926
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_6235)
Rat: Rock2, RHO-ASSOCIATED PROTEIN KINASE 2.
Mouse: Rock2, RHO-ASSOCIATED PROTEIN KINASE 2.
Human: ROCK2, RHO-ASSOCIATED PROTEIN KINASE 2.

Annotations for Rock2 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
actin cytoskeletonCNR ISS 
intracellularCIEA RCA ISS IEA 
membraneCIEA IEA 
cytoplasmCIEA IEA 
zinc ion bindingFIEA IEA IEA 
nucleotide bindingFIEA IEA IEA 
diacylglycerol bindingFIEA IEA IEA 
ATP bindingFIEA IEA IEA IEA 
protein serine/threonine kinase activityFTAS IEA IEA ISS IEA 
actin bindingFRCA ISS 
metal ion bindingFIEA IEA IEA 
protein bindingFIPI IPI ISS IEA 
structural molecule activityFNAS ISS 
protein kinase activityFIEA 
transferase activityFIEA IEA IEA 
kinase activityFIEA TAS 
protein amino acid phosphorylationPTAS IEA ISS IEA 
actin cytoskeleton organization and biogenesisPIGI 
muscle contractionPNR ISS 
signal transductionPRCA ISS 
intracellular signaling cascadePIEA IEA IEA 
chromosome condensationPTAS 
cytokinesisPNAS IEA ISS IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (5)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
embryogenesis phenotypeMPUn
lethality-embryonic/perinatalMPUn
cardiovascular system phenotypeMPUn
growth/size phenotypeMPUn
life span-post-weaning/agingMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (6)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Pathogenic Escherichia coli infection - EHEC (05130)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
TGF-beta signaling pathway (04350)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pathogenic Escherichia coli infection - EPEC (05131)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Leukocyte transendothelial migration (04670)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Wnt signaling pathway (04310)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Regulation of actin cytoskeleton (04810)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Axon guidance (04360)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Focal adhesion (04510)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway