IpiRecord: IPI00126861

IPI00126861 - Tgm2, PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2.
Uniprot Accession: P21981
Uniprot ID: TGM2_MOUSE
Mapping: Chr 2, 157807843 - 157837877
Entrez Gene: 21817
Entrez MapView: Geneprod
MGI: MGI:98731
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4154)
Rat: Tgm2, TRANSGLUTAMINASE 2, C POLYPEPTIDE.
Mouse: Tgm2, PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2.
Mouse: Tgm2, FULL INSERT SEQUENCE.
Mouse: Tgm2, TRANSGLUTAMINASE 2, C POLYPEPTIDE.
Human: TGM2, ISOFORM 2 OF PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2.
Human: TGM2, ISOFORM 3 OF PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2.
Human: TGM2, ISOFORM 1 OF PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 2.

Annotations for Tgm2 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmCISS 
membraneCTAS 
plasma membraneCIDA 
cytosolCTAS 
proteinaceous extracellular matrixCTAS 
mitochondrionCIDA 
protein serine/threonine kinase activityFISS 
enzyme bindingFIC 
metal ion bindingFIEA 
calcium ion bindingFNAS 
GTP bindingFNAS IDA 
acyltransferase activityFIEA 
protein domain specific bindingFIPI 
cysteine-type endopeptidase activityFRCA ISS 
transferase activityFIEA 
protein-glutamine gamma-glutamyltransferase activityFIMP IDA ISS 
positive regulation of cell adhesionPIMP 
G-protein coupled receptor protein signaling pathwayPTAS 
activation of NF-kappaB transcription factorPISS 
elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)PIMP 
release of cytoplasmic sequestered NF-kappaBPISS 
histone phosphorylationPISS 
induction of apoptosisPIDA 
positive regulation of inflammatory responsePIMP 
isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysinePIDA 
positive regulation of smooth muscle cell proliferationPIDA 
positive regulation of I-kappaB kinase/NF-kappaB cascadePIMP 
protein homooligomerizationPIDA IDA 
proteolysisPRCA ISS 
blood vessel remodelingPIMP 
peptide cross-linkingPTAS IEA 
histone acetylationPISS 
protein oligomerizationPISS 
G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)PISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (10)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
behavior/neurological phenotypeMPUn
immune system phenotypeMPUn
nervous system phenotypeMPUn
hematopoietic system phenotypeMPUn
no phenotypic analysisMPUn
life span-post-weaning/agingMPUn
abnormal apoptosisNISS
dilated left ventricleNISS

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
Huntington disease pathwayWIEA

KEGG Pathway (1)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Huntington's disease (05040)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway